In this study they looked at the specificity of the oligoclonal bands and came to the conclusion that they react to nothing that is consistent. We (the Royal we..i.e. one) have been hunting for years and the same answer has been there in every, yep every study….in that there is no consistent target in the oligolonal bands.
B cells get in the CNS an survive for a very long time.
MD2 came up with an idea that you don’t need to have specific oligoclonal bands. A better idea than most I think.
They are important as they keep the glia activated.
Oligoclonal IgG antibodies in multiple sclerosis target patient-specific peptides. Graner M, Pointon T, Manton S, Green M, Dennison K, Davis M, Braiotta G, Craft J, Edwards T, Polonsky B, Fringuello A, Vollmer T, Yu X.PLoS One. 2020 Feb 21;15(2):e0228883.
But hey what do I know