ArchiveFebruary 2020

DMT churn

Please note that I am so conflicted when it comes to giving advice about DMTs that you need to take what I say and think with a ‘pinch of salt’; including the contents of this post.  Meaning: To take something with a “grain of salt” or “pinch of salt” is an English language idiom that means to view something with scepticism or not to interpret something literally. The...

Anti-Clotting agent for alemtuzumab

Alemtuzumab is a very good drug, but the problem is the side-effects issues that develop of which their are many and ever increasing it seems. However with the warnings about cardic risk, a change in label and alternatives, I suspect it would be putting a plaster on a sinking ship. However, it can tell us some interesting biology as can the PD-1 inhibitors, which also have side-effect problems. I...

When doing research, doesn’t help your cause

As part of our remit of working with beasties, it is important for us to discuss animal work. Working on EAE is becoming a dying art….I have recently met a few colleagues who have said their ethical boards have stopped them working on EAE. The Home Orifice in the UK, who control animal experiments in the UK has EAE within its sights and so we are living on borrowed time. Indeed in Europe...

The Battle of the Bottom Feeders

Matching-adjusted comparisons demonstrate better clinical outcomes in patients with relapsing multiple sclerosis treated with peginterferon beta-1a than with teriflunomide. Newsome SD, Mokliatchouk O, Castrillo-Viguera C, Naylor ML. Mult Scler Relat Disord. 2020 Jan 17;40:101954 In a fish tank you have the bottom feeders that clear up the scraps left by others, in this report we have a battle of...

Will we be joining the Glee Club?

You asked what do I think about the news of the mastitinib trial? I guess we have to wait and see what happens when it is presented at AAN at ECTRIMS but they are reporting activity on one dose (4.5mg/kg) in PPMS and non-relapsing SPMS. This could be good news if true, but it could also be part of a buy-me report for the company. Importantly for me the higher dose was not reported to work, so...

Tea Time, HSCT inhibits brain infiltrating T cells

Extensive intrathecal T cell renewal following hematopoietic transplantation for multiple sclerosis. Harris KM, Lim N, Lindau P, Robins H, Griffith LM, Nash RA, Turka LA, Muraro PA. JCI Insight. 2020;5(2). pii: 127655. A recent study of autologous hematopoietic stem cell transplantation (AHSCT) for active relapsing-remitting multiple sclerosis (RRMS) showed efficacy in preventing disease...

Could diet be the new add-on DMT?

Barts-MS rose-tinted-odometer  ★ ★★ ★ ★ I gave my first on using diet as a potential symptomatic and disease-modifying treatment for MS and as a preventative therapeutic strategy in MS, last night. The symptomatic part of my talk was about food coma and using diet to prevent or reduce the impact of food coma. We are still studying why pwMS are so susceptible to food coma. I suspect it is because...

HSCT is shifting the Bell curve

Barts-MS rose-tinted-odometer  ★ ★ ★ The good news is that the use of autologous HSCT to treat autoimmune diseases rose (by 19%) in the European Bone Marrow Transplant registry in 2018. Importantly, this rise was predominantly due to HSCT treatment for multiple sclerosis. This would indicate that at least at the very right of the bell curve there is increasing use of a more aggressive...

DrAngry makes QM (Students) Happy

Irony of Humanization part VI and a half DrAngry not only gave you a valentine present last week, that as MD2 says “Is better than chocolate and flowers” but in the process also gave Queen Mary students a big smile, as they saw their hard effort become a paper and a new tool to help neuros give better treatment to you. Last week we saw the first publication of a new technology to...

MAKING ONCOLOGISING MS A REALITY

Barts-MS rose-tinted-odometer  N/A Yesterday’s PMSA meeting was very interesting. It is clear the field of MS is at a cross-roads and that Pharma needs the wider MS community to help them change the game. If we don’t I suspect we won’t see the next generation of treatments being developed to target the ‘real MS’ or ‘smouldering disease’. It was clear...

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