Predicting disability


Brain MRI Predicts Worsening Multiple Sclerosis Disability over 5 Years in the SUMMIT Study. Bakshi R, Healy BC, Dupuy SL, Kirkish G, Khalid F, Gundel T, Asteggiano C, Yousuf F, Alexander A, Hauser SL, Weiner HL, Henry RG; SUMMIT consortium. J Neuroimaging. 2020 Jan 29. doi: 10.1111/jon.12688. [Epub ahead of print].

BACKGROUND AND PURPOSE: Brain MRI-derived lesions and atrophy are related to multiple sclerosis (MS) disability. In the Serially Unified Multicenter MS Investigation (SUMMIT), from Brigham and Women’s Hospital (BWH) and University of California, San Francisco (UCSF), we assessed whether MRI methodologic heterogeneity may limit the ability to pool multisite data sets to assess 5-year clinical-MRI associations.

METHODS: Patients with relapsing-remitting (RR) MS (n = 100 from each site) underwent baseline brain MRI and baseline and 5-year clinical evaluations. Patients were matched on sex (74 women each), age, disease duration, and Expanded Disability Status Scale (EDSS) score. MRI was performed with differences between sites in both acquisition (field strength, voxel size, pulse sequences), and postprocessing pipeline to assess brain parenchymal fraction (BPF) and T2 lesion volume (T2LV).

RESULTS: The UCSF cohort showed higher correlation than the BWH cohort between T2LV and disease duration. UCSF showed a higher inverse correlation between BPF and age than BWH. UCSF showed a higher inverse correlation than BWH between BPF and 5-year EDSS score. Both cohorts showed inverse correlations between BPF and T2LV, with no between-site difference. The pooled but not individual cohort data showed a link between a lower baseline BPF and the subsequent 5-year worsening in disability in addition to other stronger relationships in the data.

CONCLUSIONS: MRI acquisition and processing differences may result in some degree of heterogeneity in assessing brain lesion and atrophy measures in patients with MS. Pooling of data across sites is beneficial to correct for potential biases in individual data sets.

So there you go, more population information that scans can sense that there is a poor prognositic sign. However, again it means that the scan does not inform on where you are going to be in five years. However the knowledge of potentially where you may be may help you make choices.

About the author



  • Take Two: You may not like Status Quo MOUSEDOCTOR but Please keep ‘ ROCKIN’ ALL OVER THE WORLD’ I’m a Man of 55 with MS and have an incomplete degree in Genetics. I love checking out your Blogs.Heres to all at Barts.

By MouseDoctor



Recent Posts

Recent Comments