ArchiveApril 2020

COVID Breakfast….Whilst Clapping for the NHS

Well I don’t want you to choke on your breakfast, so I have posted whilst you have your supper but there is some good news and this is that the City-Boys are making a killing out of COVID-19. I have been watching the share price of Gillead. This company makes an anti-viral drug called remdesivir. This was developed to treat Ebola virus. A couple of days ago, it took a drop with the news...

#MSCOVID19 asymmetry

Many of my colleagues have criticised and reprimanded me for being over-enthusiastic in stating that immunosuppressive MS DMTs are relatively safe for pwMS if they happen to develop COVID-19 whilst on treatment. However, the issue has been asymmetry of knowledge. I have known that patients on DMTs who get COVID-19 are doing well. This is based on knowledge acquired from multiple sources albeit...

#MSCOVID19 The Italian Experience

An Italian programme on COVID-19 infection in multiple sclerosis Maria Pia Sormani, on behalf of the Italian Study Group on COVID-19 infection in multiple sclerosisThe Lancet NeurologyPublished: April 29, 2020 Italy was the first European country to encounter the effects of the coronavirus disease 2019 (COVID-19) pandemic. The Italian Multiple Sclerosis Society (AISM), the Italian Multiple...

Covid Breakfast

Pseudoscience and COVID-19 – we’ve had enough already. Caulfield T. Nature. 2020 Apr 27. doi: 10.1038/d41586-020-01266-z. [Epub ahead of print] As you glug your bleach, disinfectant or UV yourself, people are getting fed up with pseudo science. This article suggests we should do more to debunk the myths They say “part of the scientific community’s fight against...

#MSCOVID19: pulse oximetry

If you are single I suggest going to extraordinary lengths to protect yourself if you have to self-isolate with COVID-19. You may have heard about the tragic death of a young surgical trainee who died alone at home from COVID-19 in Belfast last week. He probably died from pulmonary complications of COVID-19 that had gradually crept up on him and by the time he needed hospitalisation and...

Skin reactions with cladribine

Since 2014, i.e. three years before cladribine tablets were EMA licensed for highly active MS, we have treated well over 200 pwMS using injectable (s.c.) cladribine as an off-label immunotherapy. This has been a well received programme that helped a number of pwMS access treatment, who were either not eligible for licensed disease-modifying treatments (DMT), or chose our off-label offering over...

#MSCOVID19: vitamin D & zinc

I have already made the case for pwMS to prehabilitate, i.e. to prepare themselves for getting COVID-19. You can read my proposed prehabilitation programme on MS-Selfie. One of the topics I cover is diet and I mention that you should ensure that you are vitamin D (vD) replete. There are three ways to do this. (1) The first is to get a healthy daily exposure to sunshine (~20mins of upper body...

COVID Breakfast: Lock Down is not Good for the Mental Health of Scientists.

There a epidemic that is giving people publishing diarhhea and the scientific literture is becoming a sea of Sh1 littering the scientific media. Wasting everyones time. I guess I have to remember that scientists are people, but is this worth a publication in a high impact journal? Could it be used in the REF2021/22. This says to me that scientists are going stir crazy. Angry viruses make us sick:...

The genetic code

I like to think that we’re all more than some of our parts. But, our genetic code has us all fooled. Each and every cell has a genetic code that come to think of it probably has a lot more to say about our lives before, now and after than we’d truly like. We don’t debate that genetics have a role to play in the development of cancer, but MS has always proven to have a complex...

COVID-Breakfast. Neurology 101-Learn from the Biology: Each person with COVID19 is a perverse experiment

A couple of days ago I commented on that people without B cells and immunoglobulin (X-linked aggammaglobulinemia) making capacity were surviving COVID-19, which I feel is potential good news for people taking ocrelizumab. However I got blasted from a wee timmerous beastie called Neurology101 saying that they had people struggling with COVID-19. Were they saying Duh MD, you are wrong because here...

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