Well I don’t want you to choke on your breakfast, so I have posted whilst you have your supper but there is some good news and this is that the City-Boys are making a killing out of COVID-19. I have been watching the share price of Gillead. This company makes an anti-viral drug called remdesivir. This was developed to treat Ebola virus. A couple of days ago, it took a drop with the news...
#MSCOVID19 The Italian Experience
An Italian programme on COVID-19 infection in multiple sclerosis Maria Pia Sormani, on behalf of the Italian Study Group on COVID-19 infection in multiple sclerosisThe Lancet NeurologyPublished: April 29, 2020 Italy was the first European country to encounter the effects of the coronavirus disease 2019 (COVID-19) pandemic. The Italian Multiple Sclerosis Society (AISM), the Italian Multiple...
Covid Breakfast
Pseudoscience and COVID-19 – we’ve had enough already. Caulfield T. Nature. 2020 Apr 27. doi: 10.1038/d41586-020-01266-z. [Epub ahead of print] As you glug your bleach, disinfectant or UV yourself, people are getting fed up with pseudo science. This article suggests we should do more to debunk the myths They say “part of the scientific community’s fight against...
Skin reactions with cladribine
Since 2014, i.e. three years before cladribine tablets were EMA licensed for highly active MS, we have treated well over 200 pwMS using injectable (s.c.) cladribine as an off-label immunotherapy. This has been a well received programme that helped a number of pwMS access treatment, who were either not eligible for licensed disease-modifying treatments (DMT), or chose our off-label offering over...
COVID Breakfast: Lock Down is not Good for the Mental Health of Scientists.
There a epidemic that is giving people publishing diarhhea and the scientific literture is becoming a sea of Sh1 littering the scientific media. Wasting everyones time. I guess I have to remember that scientists are people, but is this worth a publication in a high impact journal? Could it be used in the REF2021/22. This says to me that scientists are going stir crazy. Angry viruses make us sick:...
The genetic code
I like to think that we’re all more than some of our parts. But, our genetic code has us all fooled. Each and every cell has a genetic code that come to think of it probably has a lot more to say about our lives before, now and after than we’d truly like. We don’t debate that genetics have a role to play in the development of cancer, but MS has always proven to have a complex...
COVID-Breakfast. Neurology 101-Learn from the Biology: Each person with COVID19 is a perverse experiment
A couple of days ago I commented on that people without B cells and immunoglobulin (X-linked aggammaglobulinemia) making capacity were surviving COVID-19, which I feel is potential good news for people taking ocrelizumab. However I got blasted from a wee timmerous beastie called Neurology101 saying that they had people struggling with COVID-19. Were they saying Duh MD, you are wrong because here...
Re-inventing the wheel with different expensive spokes
Technology is a wonderful thing and allows us to go new places and to go old places to ask the same question with a different tool. Thirty years ago I collected a number of different anti-macrophage antibodies and did some staining of some EAE tissue and came to the conclusion that there were loads of different subtypes of macrophage or different activation, functional status and things like...
DrAngry becomes a tooth brush
I’m afraid this is an in-joke and not because DocA is a Dentist The UK testing is woefully inadequate and people have been in lock down for a few weeks. If you live in the UK and got sick but not that sick you will not have got tested to know if you are virus positive. So you don’t know how safe it is to integrate. However the viral nose swab is not infallible. However, how many...
AAN2020. A CNS penetrant B cell targeting agent.
Today we had the good news that people with X-linked agammaglobulinaemia (XLA) can recover from COVID-19. As the form of agammaglobulinemia that is X-linked, it is much more common in males. In people with XLA, the white blood cell formation process does not generate mature B cells, which manifests as a complete or near-complete lack of proteins called gamma...