COVID Breakfast. 3Rs for animal research..We don’t give an SH1,. This is COVID time!…Before you say “Don’t move or the Monkey Gets it …….Too Late”

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Yep primates have been infected with SAR-COV-2….including via the eyes ..Yuck…Why are they doing this?

I suspect the regulators want toxicity tests of vaccines to be tested in non-human primates, so let’s make a monkey model. I wonder are they really that important?

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model. Rockx B, Kuiken T, Herfst S, Bestebroer T, Lamers MM, Oude Munnink BB, de Meulder D, van Amerongen G, van den Brand J, Okba NMA, Schipper D, van Run P, Leijten L, Sikkema R, Verschoor E, Verstrepen B, Bogers W, Langermans J, Drosten C, Fentener van Vlissingen M, Fouchier R, de Swart R, Koopmans M, Haagmans BL.Science. 2020 Apr 17. pii: eabb7314. doi: 10.1126/science.abb7314. [Epub ahead of print]PMID: 32303590.

Have a read, if interested BioRXiv on 17 March https://www.biorxiv.org/content/10.1101/2020.03.17.995639v1

and now you ask why Crab Eating Monkey?

Were they on the shelf ready to be tested.? After all we have had a paper, a few days ago saying crab eating monkeys weren’t that great and rhesus macaques were much better, so back to the drawing board. They also said the marmoset were a bit rubbish

Then you can see below with a bit of testing you didn’t need to do the study in the new world monkeys because they would not work as well as humans

Comparative ACE2 variation and primate COVID-19 riskAmanda D. Melin, Mareike C. Janiak, Frank Marrone, Paramjit S. Arora, James P. HighambioRxiv 2020.04.09.034967; doi: https://doi.org/10.1101/2020.04.09.034967

Problem is, Do it properly and you have missed your Science paper, your next grant and the fame and fortune.. So you can do it by the book or you can go somethere, where they really don’t care enough.

This is the same with animal experiments for MS…move East or West and it is so much easier to do animal work than in the UK :-(.

The Home Orifice Animals section have been clearing their desks to just work on the COVID animal work…..Why bother…it’s all being done elsewhere 🙁

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