You have already heard that there is interest that an anti-malarial drug may be useful for COVID-19.
Of chloroquine and COVID-19.Touret F et al. Antiviral Res. (2020)
Now there was a paper that another anti-parasite agent maybe useful. The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro.Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM.mAntiviral Res. 2020 Apr 3:104787. doi: 10.1016/j.antiviral.2020.104787. [Epub ahead of print]
However, before you get your doses of sheep-dip read this.
I know that you like to get on the internet and get a supply of the latest treatments, because that is what you can expertly do. You have had years of practice of finding treatments on the internet that you can get without dealing with your neuro….Come on…Of course you do this! How many of you are still having 30 2mg biotin tablets for breakfast?
Ivermectin is all over the place it is used on millions of animals. We have already heard of a death from someone taking the anti-malaria drug used to clean aquariums. Don’t get a Darwin Award because you have been down to the pet shop.
Whilst ivermectin has been used in millions of animals that have taken this drug as it is used to kill parasites like mites that live on the surface of people and even pinworms and it has also been used by millions of people to treat parasitic helminthic worm infections that get in your eyes, if this drug had been tested in a collie dogs and a certain type of mouse. This drug would never have been invented. It could have killed “Lassie“
The drug is called ivermectin and whilst it can do many things, one thing it can do is kill nerves. It appears by targeting a chloride channel (GABA) When it was given to a mouse strain called the MDR-1 mice, it killed them because of toxicity to the nerves. In Collie Dogs there were neurological problems and I once here a story of a human who was working at a Pot farm who got neurological problems. They were controlling pot mites with avermectin a close relative of ivermectin.
Why is this relevant. There are genetic variants of a protein called P-glycoprotein. This is a drug pump that is very highly expressed in the blood vessels of the brain. It keeps fatty drugs out of the brain.
The MDR-1 mice do not have p-glycoprotein and so they cannot pump ivermectin out of the brain and this means the drugs goes into the brain, it kill nerves. It causes the problem in Collie dogs and this possibly the problem for the Pot worker. Ivermectin has been used safety in many humans , and we all know that asparin is used safely in many humans, but it can have issues.
Now as a word of warning to people with MS, it appears that p-glycoprotein is reduced in lesions and it could mean that ivermectin could be targeted into the lesional areas of the MS and so could cause damage nerve damage. You have blood brain barrier permeability issues. Therefore I would recommend that you do not use ivermectin unless under medical advice and with medical supervision.
We used this bit of biology to target drugs into lesions in mice.
Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis. Al-Izki S, Pryce G, Hankey DJ, Lidster K, von Kutzleben SM, Browne L, Clutterbuck L, Posada C, Edith Chan AW, Amor S, Perkins V, Gerritsen WH, Ummenthum K, Peferoen-Baert R, van der Valk P, Montoya A, Joel SP, Garthwaite J, Giovannoni G, Selwood DL, Baker D. Brain. 2014;137(Pt 1):92-108.
Others have shown this too
T lymphocytes impair P-glycoprotein function during neuroinflammation. Kooij G, van Horssen J, de Lange EC, Reijerkerk A, van der Pol SM, van Het Hof B, Drexhage J, Vennegoor A, Killestein J, Scheffer G, Oerlemans R, Scheper R, van der Valk P, Dijkstra CD, de Vries HE. J Autoimmun. 2010; 34(4):416-25
There you have it according to Wiki the Scots say
Lastly do not give to your tortoises…ivermecting can cross the blood brain barrier