ArchiveMay 2020

More evidence that MS-DMT are a damp squibb as far as #MSCOVID19 is concerned

COVID-19 in Multiple Sclerosis Patients and Risk Factors for Severe InfectionChaudhry, F., Bulka, H., Rathnam, A. S., Said, O. M., Lin, J., Lorigan, H., Bernitsas, E., Rube, J., Korzeniewski, S. J., Memon, A. B., Levy, P. D., Javed, A., Lisak, R., Cerghet, M.10.1101/2020.05.27.20114827 — Posted: 2020-05-29 Wow this figure is a bit vivid, but this follows the same pattern we are seeing over...

#MSCOVID19. Trial results of interferon Beta

You can read….best wishes Efficacy and safety of interferon beta-1a in treatment of severe COVID-19: A randomized clinical trialDavoudi-Monfared, E., Rahmani, H., Khalili, H., Hajiabdolbaghi, M., Salehi, M., Abbasian, L., Kazemzadeh, H., Yekaninejad, M. S.10.1101/2020.05.28.20116467 — Posted: 2020-05-30 Objectives: To the best of our knowledge, there is no published study regarding use of...

Why are many people doing OK in the #MSCOVID19 era

To get a vaccine response for COVID-19 we need antibodies but we also need T cells. CD4 T cells help macrophages and B cells and others to do their stuff. CD8 T cells are the main anti-viral cells. So studies in people infected with COVID show a clear anti-COVID response and people treated with novel COVID-19 vaccines show antibody and T cell responses (Zhu et al. Lancet. 2020 May 22:S0140...

Why have MS-DMT not impacted on #MSCOVID19 and vice versa…Simples it may not be an immune issue

Since the COVID-19 story broke we have been focusing on the immune system, because after all the immune system will ultimately get rid of the virus. We have made the point that many MS-DMT may not grossly inhibit the cells responsible for the anti-viral response and so MS-DMT may not stop you responding sufficiently to the SARS-CoV-2 virus. More recently we have been suggesting that a central...

Get you Nice Shiney (Butchered) #MSCOVID19 Review Here

The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic.David Baker, Sandra Amor, Angray S. Kang, Klaus Schmierer, Gavin GiovannoniMult Scler Relat Disord. 2020 May 12 : 102174. doi: 10.1016/j.msard.2020.102174 [Epub ahead of print]. This review has been type set and still not on pubmed. Here is the...

Has NDG cured PML?

So yesterday we went through the process of how you can kickstart the immune response to target a viral response and looked at efforts to treat COVID-19. I asked if this could be applied to PML and in conclusion said NDG had done just that already. This was not in MS but in people who had low lymphocyte levels who had got PML. If you can remember from yesterday immune check point inhibitors. One...

COVID Breafast. What’s has space travel, COVID19 and the Science self-publicity machine got in common to help MS?….Maybe Too Late! has NDG cured PML?

The Space programme gave us a man on the moon , but in the process of that a lot of innovation was developed…like the Space Pen that I carry that writes upside down and underwater. Others include Artificial limbs. …Insulin pump. …DustBusters. …Shock absorbers for buildings. …Solar cells……Cold-Weather Wearables. …Foil Blankets. …Scratch...

Alemtuzumab replay

Sometimes it’s better the devil you know than the one you don’t. Alemtuzumab came into disfavor following the European Medicines Agency (EMA) Article 20 procedure surrounding certain rare side effects. There couldn’t have been a deeper grave to crawl out of. In my mind the group most to gain from alemtuzumab have always been those early on in their disease before disability sets...

COVID Breakfast

As you know COVID breakfast is a light hearted look at the lunacy that is affecting us all. I made a little Joke about the spate of microbiome studies that have sprung up since COVID-19 arrived….However, this seems more logical than Dr Spock on Star Trek compared to the one that DrM&M told me about. The registered trial that I am frightened to talk about, is this one…NCT04361838...

Rapid memory B cell increase associated with alemtzumab failure, but where does the ABN stand on MS treatments currently.

We already know that after alemtzumab treatment there is a rapid rise in immature B cells, but in general memory B cells stay low for the first couple of years after treatment onset. However not in this case, there was a notable increase in memory B cell numbers and this person appeared to fail alemtuzumab. Is this cause and effect or just a chance finding, after all levels of lymphocytes in the...

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