ArchiveMay 2020

Get you Nice Shiney (Butchered) #MSCOVID19 Review Here

The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic.David Baker, Sandra Amor, Angray S. Kang, Klaus Schmierer, Gavin GiovannoniMult Scler Relat Disord. 2020 May 12 : 102174. doi: 10.1016/j.msard.2020.102174 [Epub ahead of print]. This review has been type set and still not on pubmed. Here is the...

Has NDG cured PML?

So yesterday we went through the process of how you can kickstart the immune response to target a viral response and looked at efforts to treat COVID-19. I asked if this could be applied to PML and in conclusion said NDG had done just that already. This was not in MS but in people who had low lymphocyte levels who had got PML. If you can remember from yesterday immune check point inhibitors. One...

#MSCOVID19: Why is cladribine so misunderstood?

Because cladribine and alemtuzumab are classified as immune reconstitution therapies (IRTs), and probably work in a similar way, they are tarnished with the same brush. However, cladribine’s immune depletion and reconstitution, and adverse event profile are very different to alemtuzumab’s and therefore cladribine should be considered on its own when weighing up the risks and benefits of...

COVID Breafast. What’s has space travel, COVID19 and the Science self-publicity machine got in common to help MS?….Maybe Too Late! has NDG cured PML?

The Space programme gave us a man on the moon , but in the process of that a lot of innovation was developed…like the Space Pen that I carry that writes upside down and underwater. Others include Artificial limbs. …Insulin pump. …DustBusters. …Shock absorbers for buildings. …Solar cells……Cold-Weather Wearables. …Foil Blankets. …Scratch...

East Africa and MS

COVID-19 impact has extended to East Africa. Instead of a face-to-face meeting, the East African Neurologists have moved their CPD (continuing professional development) online in the form or regular webinars. In the past, I would probably have had to travel to East Africa to give a guest lecture at their annual meeting. Post-COVID-19 I can now do this online, which is a much cheaper and greener...

Alemtuzumab replay

Sometimes it’s better the devil you know than the one you don’t. Alemtuzumab came into disfavor following the European Medicines Agency (EMA) Article 20 procedure surrounding certain rare side effects. There couldn’t have been a deeper grave to crawl out of. In my mind the group most to gain from alemtuzumab have always been those early on in their disease before disability sets...

COVID Breakfast

As you know COVID breakfast is a light hearted look at the lunacy that is affecting us all. I made a little Joke about the spate of microbiome studies that have sprung up since COVID-19 arrived….However, this seems more logical than Dr Spock on Star Trek compared to the one that DrM&M told me about. The registered trial that I am frightened to talk about, is this one…NCT04361838...

Rapid memory B cell increase associated with alemtzumab failure, but where does the ABN stand on MS treatments currently.

We already know that after alemtzumab treatment there is a rapid rise in immature B cells, but in general memory B cells stay low for the first couple of years after treatment onset. However not in this case, there was a notable increase in memory B cell numbers and this person appeared to fail alemtuzumab. Is this cause and effect or just a chance finding, after all levels of lymphocytes in the...

Is you current interferon beta treatment any benefit against #MSCOVID19

Interferons in the Therapy of Severe Coronavirus Infections: A Critical Analysis and Recollection of a Forgotten Therapeutic Regimen with Interferon Beta.Brzoska J, von Eick H, Hündgen M.Drug Res (Stuttg). 2020 May 22. doi: 10.1055/a-1170-4395. Online ahead of print.PMID: 32443163 There is a question about whether interferon B can be used for the treatment of COVID-19. This is because interferons...

COVID breakfast

The Good news for Cats is that they are apparently off the menu in China the bad news that they can get COVID-19, but fear not it was asymptomatic Detection of SARS-CoV-2 in pets living with COVID-19 owners diagnosed during the COVID-19 lockdown in Spain: A case of an asymptomatic cat with SARS-CoV-2 in EuropeRuiz-Arrondo, I., Portillo, A., Palomar, A. M., Santibanez, S., Santibanez, P., Cervera...

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