Has NDG cured PML?


So yesterday we went through the process of how you can kickstart the immune response to target a viral response and looked at efforts to treat COVID-19. I asked if this could be applied to PML and in conclusion said NDG had done just that already. This was not in MS but in people who had low lymphocyte levels who had got PML.

If you can remember from yesterday immune check point inhibitors. One check-point inhibitor is called pembroluzimab. These are agents that are used to kick start an immune response to fight cancer, but there is an idea that you can do this to help create an anti-viral response. However,without enough T cells there to do the job it is hard for these to work, so rather than use interleukin 7, NDG used interleukin-2. This is known as the T cell growth factor, to create a T cell pool and in this case report the so called untreatable JC virus was removed. Chance event or a cure? You decide, but it creates a path forward. If NDG was in the Institute of Self-Publicity the Beeb would have been filming already.

Sequential interleukin 2 and pembrolizumab use in progressive multifocal leukoencephalopathy.Mahler C, Andrews M, Henson SM, Gnanapavan S.Neurol Neuroimmunol Neuroinflamm. 2020 May 20;7(4):e756. doi: 10.1212/NXI.0000000000000756. Print 2020 Jul.

Its free so have a read

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  • What is NDG, pray ?
    As well, pembrolizumab (these MAbs are getting tougher to pronounce and remember and soon will need an ‘App for that’), which blocks a negative regulator of programmed cell death-1 protein (PD-1 expression is blocked) and therefore helps viral clearance. What is the difference between IL-2 blockade vs the action of Pembrolizumab ? I guess there are obvious pathway-specific MOA (mode of action) issues and considerations and side-effects of course, but efficacy wise, there are perhaps miles to go…..

    • You clearly are not a regular look at am Tuesday at midnight to get a hint of who NDG maybe.
      Not IL2 blockade buy IL2 stimulation

  • In the case of Tysabri and PML, I did not think we were T-cell depleted? Was I wrong? How do they know the JC Virus was removed? Titers?

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