So yesterday we went through the process of how you can kickstart the immune response to target a viral response and looked at efforts to treat COVID-19. I asked if this could be applied to PML and in conclusion said NDG had done just that already. This was not in MS but in people who had low lymphocyte levels who had got PML.
If you can remember from yesterday immune check point inhibitors. One check-point inhibitor is called pembroluzimab. These are agents that are used to kick start an immune response to fight cancer, but there is an idea that you can do this to help create an anti-viral response. However,without enough T cells there to do the job it is hard for these to work, so rather than use interleukin 7, NDG used interleukin-2. This is known as the T cell growth factor, to create a T cell pool and in this case report the so called untreatable JC virus was removed. Chance event or a cure? You decide, but it creates a path forward. If NDG was in the Institute of Self-Publicity the Beeb would have been filming already.
Sequential interleukin 2 and pembrolizumab use in progressive multifocal leukoencephalopathy.Mahler C, Andrews M, Henson SM, Gnanapavan S.Neurol Neuroimmunol Neuroinflamm. 2020 May 20;7(4):e756. doi: 10.1212/NXI.0000000000000756. Print 2020 Jul.
Its free so have a read