As Part of the PROMIS 2010 , Prof Goldman presented this data. I remember it well as the suppossedly 10minute talk went on for about 40minutes. It demonstrated that human brain cells could myelinate shivering mice who naturally do not make myelin. In this study they showed they can do this in a demyelinated mice. So next step human trials. This is eligantly shows us what has been shown by others that progenitors can make new myelinating cells and shows us that if damage occurs they can repair. However, but I do remeber that to adequately myelinate the mouse took a long, long time.
So the plan is human studies, however this approach has many, many difficulties and many researchers have been ready to do these types of study for many years. In MS there is damage all over the place. Would your CNS be like a pin cusshion of injections to fix the lesions and how long is it going to take to deal with a human to repair something that is 100 times bigger than a mouse. I guess we will have to watch this space.
Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.Windrem MS, Schanz SJ, Zou L, Chandler-Militello D, Kuypers NJ, Nedergaard M, Lu Y, Mariani JN, Goldman SA.Cell Rep. 2020 May 19;31(7):107658. doi: 10.1016/j.celrep.2020.107658.
Neonatally transplanted human glial progenitor cells (hGPCs) can myelinate the brains of myelin-deficient shiverer mice, rescuing their phenotype and survival. Yet, it has been unclear whether implanted hGPCs are similarly able to remyelinate the diffusely demyelinated adult CNS. We, therefore, ask if hGPCs could remyelinate both congenitally hypomyelinated adult shiverers and normal adult mice after cuprizone demyelination. In adult shiverers, hGPCs broadly disperse and differentiate as myelinating oligodendrocytes after subcortical injection, improving both host callosal conduction and ambulation. Implanted hGPCs similarly remyelinate denuded axons after cuprizone demyelination, whether delivered before or after demyelination. RNA sequencing (RNA-seq) of hGPCs back from cuprizone-demyelinated brains reveals their transcriptional activation of oligodendrocyte differentiation programs, while distinguishing them from hGPCs not previously exposed to demyelination. These data indicate the ability of transplanted hGPCs to disperse throughout the adult CNS, to broadly myelinate regions of dysmyelination, and also to be recruited as myelinogenic oligodendrocytes later in life, upon demyelination-associated demand.