ArchiveMay 2020

East Africa and MS

COVID-19 impact has extended to East Africa. Instead of a face-to-face meeting, the East African Neurologists have moved their CPD (continuing professional development) online in the form or regular webinars. In the past, I would probably have had to travel to East Africa to give a guest lecture at their annual meeting. Post-COVID-19 I can now do this online, which is a much cheaper and greener...

Alemtuzumab replay

Sometimes it’s better the devil you know than the one you don’t. Alemtuzumab came into disfavor following the European Medicines Agency (EMA) Article 20 procedure surrounding certain rare side effects. There couldn’t have been a deeper grave to crawl out of. In my mind the group most to gain from alemtuzumab have always been those early on in their disease before disability sets...

COVID Breakfast

As you know COVID breakfast is a light hearted look at the lunacy that is affecting us all. I made a little Joke about the spate of microbiome studies that have sprung up since COVID-19 arrived….However, this seems more logical than Dr Spock on Star Trek compared to the one that DrM&M told me about. The registered trial that I am frightened to talk about, is this one…NCT04361838...

Rapid memory B cell increase associated with alemtzumab failure, but where does the ABN stand on MS treatments currently.

We already know that after alemtzumab treatment there is a rapid rise in immature B cells, but in general memory B cells stay low for the first couple of years after treatment onset. However not in this case, there was a notable increase in memory B cell numbers and this person appeared to fail alemtuzumab. Is this cause and effect or just a chance finding, after all levels of lymphocytes in the...

Is you current interferon beta treatment any benefit against #MSCOVID19

Interferons in the Therapy of Severe Coronavirus Infections: A Critical Analysis and Recollection of a Forgotten Therapeutic Regimen with Interferon Beta.Brzoska J, von Eick H, Hündgen M.Drug Res (Stuttg). 2020 May 22. doi: 10.1055/a-1170-4395. Online ahead of print.PMID: 32443163 There is a question about whether interferon B can be used for the treatment of COVID-19. This is because interferons...

COVID breakfast

The Good news for Cats is that they are apparently off the menu in China the bad news that they can get COVID-19, but fear not it was asymptomatic Detection of SARS-CoV-2 in pets living with COVID-19 owners diagnosed during the COVID-19 lockdown in Spain: A case of an asymptomatic cat with SARS-CoV-2 in EuropeRuiz-Arrondo, I., Portillo, A., Palomar, A. M., Santibanez, S., Santibanez, P., Cervera...

Do you do your Science like your literature review?

Is there is a nasty little fact that we ignore as it doesn’t suit our case? We are desperate to be first to publish stuff. But if you don’t come first. Is it OK to ignore other peoples work to make it look like yours is more important? Because if you are willing to do this, what else do you ignore? This is relevant to MS because we see this and that paper on animal studies in Nature...

#MSCOVID19 Anti-CD20 therapies and vaccines

Have we optimised the dose of anti-CD20 therapies to target the real MS or smouldering MS, i.e. disease progression independent of relapse activity (PIRA)? I did an iWiMS webinar on Wednesday covering anti-CD20 therapies and the risk of COVID-19 and severe COVID-19. I covered vaccine responses and how to be vaccine-ready or vaccine responsive to a future SARS-CoV-2 vaccine if you are on an anti...

#MSCOVID19 info wars

It is one thing calling for scientists to turbocharge the development of a coronavirus vaccine but quite another to get the population to have the vaccine. The anti-vaxxers are organising rapidly and have started circulating content with false information to achieve their aims. The movie plandemic is one example and is covered in a very good article in the New York Times today.   The primary...

#MSCOVID-19: how to prevent yourself from getting COVID-19 in your own home

What can do I to prevent myself from being infected with coronavirus if someone in my household gets COVID-19?  This is a topic that I have not covered directly, but it is obviously very important and an oversight on my part. Apologies.  The following advice is pretty intuitive and has been hacked from an amazing website, by the Univesity of Southampton, called Germ Defence. If you have the...

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