Here it the Roche Ocrelizumab data presented by Heinz Weindl at the International Women in MS Meeting presented May 5th
So with 100 cases 26% were hospitalised, 5% went to ICU and at the time of writing 3/5 are still touch and go…Is this scary if you are on ocrelizumab?….Are they hiding anything…well I think there is a chance that some people could die as people on ventilation have a higher risk. However, to me this is the good news at present, in that analysis says there were no deaths. Now, I know there has been at least one, but it is not the avalanche that the immunosuppression doom and gloomers gave us two months ago. Is the 26% having a tough time significant, maybe may be not, you can have your own opinions. Is it relevant that there was 100 cases does it put you at more risk. This will will come out in the wash.
Personally I applaud Roche for releasing this data. If you are any other company, I will happily put your story up too. If you are a cynic you can say they are spinning things, but I say there are plenty of other cases out there and the truth will be out. It is not just MS and ocrelizumab, but arthritis and NMO and MS etc in people taking rituximab
Did I put it up to say let’s all use ocrelizumab…..No.
I put this information up to give people who have taken ocrelizumab some insight and hope it eases some fears. This data is in the public domain. There is more data.
If people can assimilate the data for the other studies I will put it up too. I have not had time to summate the data in the public domain. If I get time I may do this.
If you want to make issue that ocrelizumab give more severe data, you can.
A possible role for B cells in COVID-19?: Lesson from patients with Agammaglobulinemia. Quinti I, Lougaris V, Milito C, Cinetto F, Pecoraro A, Mezzaroma I, Mastroianni CM, Turriziani O, Bondioni MP, Filippini M, Soresina A, Spadaro G, Agostini C, Carsetti R, Plebani A. J Allergy Clin Immunol. 2020 Apr 22. pii: S0091-6749(20)30557-1.
Well I sure Prof Weindl will still get a publication and apologises to him for outing the information…but who knows this could be 3 months down the line.
P.S. This is updated I made a mistake originally read below.