ProfG caused a stir when he suggested that people taking anti-CD20 may be at a small increased risk of developing COVID-19. However, would we expect this?. If it makes a small increased risk of other infections. why not this one?
However, the other reality that we could predict ,was that if you have no B cells it is going to be more difficult to make antibody responses to SARS-CoV-2.
In this case report 7 people get infected, 3 get hospitalised some made an antibody response, but others did not despite being tested positive with the viral DNA . So will CD20 depletion inhibit capacity to make a a full vaccine response? I suspect the answer is yes. It’s biology 101.
COVID-19 IN 7 MULTIPLE SCLEROSIS PATIENTS IN TREATMENT WITH ANTI-CD20 THERAPIES Dra. Virginia Meca-Lallana, Dra. Clara Aguirre, Beatrizdel Río, Dra. Laura Cardeñoso, … Dr. José Vivancos Mult Scler Rel Disord In Press, Journal Pre-proof, Available online 15 June 2020.
Now one of the people was asyptomatic and did not make an antibody response but even people who don’t have DMT treatment do not make an antibody response. But there was one person who was symptonmatic but didn’t make an antibody response. There are others
So the question is….Is the antibody response enough to give protection against SARS-CoV-2?