You do not need peripheral B cells in the blood to fight COVID-19 so does that mean it is T-time for the T cells to get rid of COVID-19.
Woo, M.S., Steins, D., Häußler, V. et al. Control of SARS-CoV-2 infection in rituximab-treated neuroimmunological patients. J Neurol (2020). https://doi.org/10.1007/s00415-020-10046-8.
If they had read our paper…… The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic.Baker D, Amor S, Kang AS, Schmierer K, Giovannoni G.Mult Scler Relat Disord. 2020 May 12;43:102174. doi: 10.1016/j.msard.2020.102174. …..They would have known this.
Alemtuzumab is the sledge hammer to MS and it depletes your T and B cells and your MS goes away. So does your protective immune response, at least for a few weeks and this can be seen by the need to use treatments such as Acylovir to reduce viral infections. What happens to you when you get COVID-19..you may predict disaster…howeverwe have made the case that the innate immune response is numero uno when it comes to kicking COVID-butt. The clinical experiment will give us the answer and there are a few case reports that support this view and the best one has just surfaced.
COVID-19 and multiple sclerosis: A description of two cases on alemtuzumab Eva Fernández-Díaz, Julia Gracia-Gil, Jose Gregorio García-García, María Palao, Carlos M Romero-Sánchez, Tomás SeguraDOI: https://doi.org/10.1016/j.msard.2020.102402
In previous study an individual that recovered after getting COVID 2 weeks after alemtuzumab had low (paenic) white blood cells was lymphopaenic (90 cells /microlitre) and neutropaenic (75 cells /microlitre).
Was this a fluke?. Well you may remember a London Neuro thought they had a pwMS who had COVID-19 2 weeks after infusion. The problem was there was no confirmation.
However this is the best case report on alemtuzumab and says that lymphocyte levels in the blood can be essentially zero and you can still recover from COVDI19
multiple sclerosis: a description of two cases on alemtuzumab. There were zero lymphocytes at the time of infection and only 160 cells/microlitre which is grade 4 lymphopenia (below 200 cells/microlitre) compared to the lower limit of normal at 1000 cells/microlitre = 1,000,000,000 per litre of blood )
However let’s look at the innate immune (monocytes and polymophonuclear neutrophils (PMN) response
You can see that the innate immune response comes to the rescue, also you will notice that an anti-COVID-2 response is produced, just as I predicted.
Alemtuzumab is clearing the blood, but not the lymph glands one suspects,