ArchiveSeptember 2020

#MSCOVID19: dropping dead

Barts-MS rose-tinted-odometer: ★★★★★ “Did you hear that Professor Giovannoni dropped dead after attempting to complete the virtual New York Marathon trying to raise money for a multiple sclerosis research project?”  “Prog G finally throws in the towel and arranges to see an orthopaedic surgeon about his failing right hip. His attempt to complete a marathon to raise money for MS research was one...

#MSCOVID19 & education: changing the way we manage MS one young brain at a time

Barts-MS rose-tinted-odometer: ★★★★★ At Barts-MS we spend a lot of time teaching people about MS. It is not only important to generate new information (ideas, testable hypotheses and research), but also to disseminate knowledge (teaching). However, with the COVID-19 pandemic and the resultant social distancing, almost all teaching has gone online and that does not make for very engaging and...

#MSCOVID19 . Looking at the risk

Bsteh G, Bitschnau C, Hegen H, Auer M, Di Pauli F, Rommer P, Deisenhammer F, Berger T. Multiple sclerosis and COVID-19: how many are at risk? Eur J Neurol. 2020 Sep 25. doi: 10.1111/ene.14555.  Background: The COVID-19 pandemic challenges neurologists in counselling multiple sclerosis (MS) patients with respect to their risk for and by SARS-CoV-2 and in guiding disease-modifying treatment...

Plot thickens: MS versus other antibody disorders

The MSVirtual2020 late breaking news was announced this weekend. Despite a diagnostic biomarker for neuromyelitis optica (the Aquaporin 4 antibody), it remains difficult differentiate NMO from MS clinically. Dr David Leppert from Basel, Switzerland presented their findings on biomarkers of the innate immune system, focusing on neutrophil activity markers (a type of immune cell) in the...

CD20 The Next Generation. Will they be neuroprotective?

Optimising B-cell depletion in autoimmune disease: is obinutuzumab the answer?Reddy V, Dahal LN, Cragg MS, Leandro M.Drug Discov Today. 2016 Aug;21(8):1330-8.  In Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE), B-cell depletion therapy using rituximab results in variable clinical responses between individuals, which likely relates to variable B-cell depletion in...

#MSCOVID19: digital health – what will survive?

Barts-MS rose-tinted-odometer: ★★★ I am doing a webinar with Professor Tjalf Ziemssen, a good friend and colleague from Dresden, Germany, this afternoon on the digital management of MS. Interestingly, many of the changes and innovations we have put in place to manage MS during the COVID-19 pandemic will survive and actually thrive in the new NHS, simply because we are a socialist healthcare...

#MSCOVID19: good news

Barts-MS rose-tinted-odometer: ★★★★★ The late late-breaking session at the MSVirtual2020 meeting, which covered COVID-19 has already received a lot of air-time on social media. The big-data alliance confirmed the Italian data, i.e. that people with MS (pwMS) on anti-CD20 are at higher risk of getting COVID-19 and severe COVID-19 (hospitalisation, intensive care admission and/or ventilation)...

MD2

ProfG wants the real MS to stand-up and asks about smouldering lesions. We think that hot microglia at the centre of these. A few years ago MD2 came up with the idea that antibodies within the oligoclonal bands could activate microglial by binding to receptors on the microglia and that may mean that it doesn’t matter what the antibodies are reactive against, so stop looking for anti-myelin...

Remyelination here we come…well almost. Bexarotene trial ECTRIMS

The basic science gives the tools for the clinicians to try and find treatments and Prof Franklinstein (Robin Franklin) from Cambridge and Prof ffffffffffrench-constant from Edinburgh hunted for molecules that may affect switches from precursors cells to full myelinating cells. They came up with a target that is triggered by the retinoid X receptor (RXR) gamma. Prof Franklin tried to get...

#MSCOVID19 Will CD20 treatment make you into a shedder

Typically when infected with SARS-CoV-2, you make an immune response and you get rid of the virus. But if you do not have an effective immune sytstem you can’t get rid of the virus and you can become a super spreader. Here is an interesting case that is not MS, but if you are CD20 depleting and you get that dry cough, fever and loss of smell think about your fellow humans and self-isolate...

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