ArchiveSeptember 2020

#MSCOVID19 . Looking at the risk

Bsteh G, Bitschnau C, Hegen H, Auer M, Di Pauli F, Rommer P, Deisenhammer F, Berger T. Multiple sclerosis and COVID-19: how many are at risk? Eur J Neurol. 2020 Sep 25. doi: 10.1111/ene.14555.  Background: The COVID-19 pandemic challenges neurologists in counselling multiple sclerosis (MS) patients with respect to their risk for and by SARS-CoV-2 and in guiding disease-modifying treatment...

Plot thickens: MS versus other antibody disorders

The MSVirtual2020 late breaking news was announced this weekend. Despite a diagnostic biomarker for neuromyelitis optica (the Aquaporin 4 antibody), it remains difficult differentiate NMO from MS clinically. Dr David Leppert from Basel, Switzerland presented their findings on biomarkers of the innate immune system, focusing on neutrophil activity markers (a type of immune cell) in the...

CD20 The Next Generation. Will they be neuroprotective?

Optimising B-cell depletion in autoimmune disease: is obinutuzumab the answer?Reddy V, Dahal LN, Cragg MS, Leandro M.Drug Discov Today. 2016 Aug;21(8):1330-8.  In Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE), B-cell depletion therapy using rituximab results in variable clinical responses between individuals, which likely relates to variable B-cell depletion in...

MD2

ProfG wants the real MS to stand-up and asks about smouldering lesions. We think that hot microglia at the centre of these. A few years ago MD2 came up with the idea that antibodies within the oligoclonal bands could activate microglial by binding to receptors on the microglia and that may mean that it doesn’t matter what the antibodies are reactive against, so stop looking for anti-myelin...

#MSCOVID19 Will CD20 treatment make you into a shedder

Typically when infected with SARS-CoV-2, you make an immune response and you get rid of the virus. But if you do not have an effective immune sytstem you can’t get rid of the virus and you can become a super spreader. Here is an interesting case that is not MS, but if you are CD20 depleting and you get that dry cough, fever and loss of smell think about your fellow humans and self-isolate...

T cells in MS brain

The central nervous system (CNS) features mechanisms to protect against untoward inflammation yet allowing immune surveillance for pathogens. Pappalardo et al. profiled T cells in the cerebrospinal fluid (CSF) of healthy individuals and patients with multiple sclerosis (MS) using single-cell RNA and TCR sequences to define CNS immune homeostasis in both healthy and patients with MS. In...

Confessions of an ECTRIMS fellow: what I really learned during my BartsMS fellowship

As you might have captured in one of my preceding blog posts, I’m relatively new to the MS research blog. There is a logical explanation for this: I only started to work at BartsMS in November 2019. With the purpose of converting me in an MS-ologist, I was one of the fortunate people to receive a clinical fellowship grant from the European MS association ‘ECTRIMS’.   The preceding ten...

ProfG has turned into a Smurf…Dear Neuro stop him turning into Papa!

ProfG has been banging-on about “Treat early and effectively to save brain”, until he is blue in the face….So much so, that he has turned into a Smurf Sadly there are still many of his colleagues that don’t buy into this… and follow the mantra of “There….There, we’ll get ya a nice wheel chair” The vast majority of neuros and pharma bods still...

Shot down in flames before the VirtualMS dust has settled

Last weekend marked the eightieth anniversary of the Battle of Britain. In 1940, many planes were shot down in flames. Whilst this can happen to planes, this can also happen to ideas. Some of them take some time to be shot down, but sometimes they it takes less time. Who would have thought that some are shot down before they take off! This is super scientific so read on if interested OK not alot...

T cells bite the dust

An interesting presentation from this years MSVirtual2020 was presentation by Dr Beatrice Wasser on ‘GlcNac signalling to reduce T cell pathogenicity in MS’. Abstract Background: Both adaptive and innate immune cells infiltrate the CNS during multiple sclerosis (MS) and in its animal model experimental autoimmune encephalomyelitis (EAE). Pathogenic T cells are known as key drivers of...

Translate

Categories

Recent Posts

Recent Comments

Archives