ArchiveSeptember 2020

T cells bite the dust

An interesting presentation from this years MSVirtual2020 was presentation by Dr Beatrice Wasser on ‘GlcNac signalling to reduce T cell pathogenicity in MS’. Abstract Background: Both adaptive and innate immune cells infiltrate the CNS during multiple sclerosis (MS) and in its animal model experimental autoimmune encephalomyelitis (EAE). Pathogenic T cells are known as key drivers of...

MSVirtual2020 #SoWhite

Last week, I sat down and watched this year’s virtual joint ECTRIMS/ACTRIMS Congress – the world’s largest annual conference dedicated to multiple sclerosis. Over three days, nearly two hundred leading MS clinicians, scientists and health care professionals appeared on the screen presenting the latest research and treatment on the disease. Most of them, I noticed, were White. Not...

Natalizumab EDI

As you all know natlaizumab is typically dosed at 4 week intervals = standard dose interval. This stops lymphocytes and probably monocytes entering the brain and so stops immune survellience of the brain, exposing people to risks of brain infection with JC virus that causes PML By extending the interval to 6 weeks (extended dosing interval = EDI). This seems to reduce the risk of PML without...

It’s not just MS #mscovid19

I haven’t done one of these for a while. The CoOVID-19 publication epidemic has continued at a rate of knots and there is lots of stuff to give us a laugh. So you may not be surprised that COVID-19 in the UK and USA has made us rush to the drinks cabinet Problem drinking before and during the COVID-19 crisis in US and UK adults: Evidence from two population-based longitudinal studies...

#MSCOVID19: the new lepers?

Barts-MS rose-tinted-odometer: ★★★ Early this week my wife came down with a cold. Did she have coronavirus was the immediate question? She asked me for advice and I said she had better get herself swabbed and in the interim we should isolate ourselves. All she had was a mild headache (sinus-type), runny nose, sneezing and a sore throat. She did not have a temperature and only developed a mild...

What is MTR?

What is MRI? is one of the most read educational pieces on the blog. MRI lets us look in the brain, but the problem is no one really knows what the images mean. They corelate with this and they correlate with that, which means it has a woolly relationship with anything. MTR (magnetization transfer ratio) is going to be an important one because it is being used to assess the sucess of...

VV where are you?

Anyone who have been a long-term reader of the blog know that every now and then a character comes along who likes to challenge the team. The nemesis of TeamG and the peoples champion who wants to “Stick it to the man” We get Sid from the Cup (Siddcup) and then we had DrDre the rapper from Bradford . ProfG used to get his character assassinated by Joanie and for those with a distant...

Pregnacy delays MS

Queen Victoria used to have terrible period pains…so how did she get rid of this…yep she had 10 kids and so must have been constantly pregnant or was it a way to keep MS at bay? Women with previous pregnancies and childbirths had a later onset of CIS compared with those who had never been pregnant with a median delay of 3.3 (95% CI, 2.5-4.1) years. How would this work…hormones I...

Fancy genetic stuff tells us..guess what?..Yep that memory B cells are useful targets..OK I’m biased:-)

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.Orrù V, Steri M, Sidore C, Marongiu M, Serra V, Olla S, Sole G, Lai S, Dei M, Mulas A, Virdis F, Piras MG, Lobina M, Marongiu M, Pitzalis M, Deidda F, Loizedda A, Onano S, Zoledziewska M, Sawcer S, Devoto M, Gorospe M, Abecasis GR, Floris M, Pala M, Schlessinger D, Fiorillo E, Cucca F.Nat Genet. 2020 Sep 14. doi:...

#MSCOVID19: European COVID-19 Cup Quarterfinals

There has been a lot of debate about which country has had the best strategy at dealing with their coronavirus epidemic. It is clear based on the epidemiology of pandemics that countries needed to play with the mid and end game in mind. We are now quite a way into the COVID-19 pandemic and have reached the quarterfinals stage. Which countries do you think are going to win the quarterfinals and...

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