#MSCOVID19 Will CD20 treatment make you into a shedder

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Typically when infected with SARS-CoV-2, you make an immune response and you get rid of the virus. But if you do not have an effective immune sytstem you can’t get rid of the virus and you can become a super spreader.

Here is an interesting case that is not MS, but if you are CD20 depleting and you get that dry cough, fever and loss of smell think about your fellow humans and self-isolate as you dont want to be a spreader.

Prolonged SARS-CoV-2 replication in an immunocompromised patientBaang, J. H., Smith, C., Mirabelli, C., Valesano, A. L., Manthei, D. M., Bachman, M., Wobus, C. E., Adams, M., Washer, L., Martin, E. T., Lauring, A. S.10.1101/2020.09.20.20196899 — Posted: 2020-09-22

We describe a case of chronic COVID-19 in a patient with lymphoma and associated B-cell immunodeficiency. Viral cultures and sequence analysis demonstrate ongoing replication of infectious SARS-CoV-2 virus for at least 119 days. The patient had three admissions related to COVID-19 over a four-month period and was treated twice with remdesivir and convalescent plasma with resolution of symptoms. The lack of seroconversion and prolonged course illustrate the importance of humoral immunity in resolving SARS-CoV-2 infection. This case highlights challenges in managing immunocompromised hosts, who may act as persistent shedders and sources of transmission.

So it suggests antibodies may be important for the vaccine response and maybe if you get infected and cant get rid of the virus could could become a virus super spreader

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