It seems that there have been fewer cases of Flu in Australia this Winter, possibly because people have been socially distancing. I am on the waiting list for this years flu jab and am not going to get an offer until the Heath Care professionals and others have been offered their Jab. Are you an anti-Jaxer but want to avoid COVID-19. But maybe vaccination against Flu can reduce your risk f COVID-19…Maybe worth getting this years jab
Debisarun PA et al.The effect of influenza vaccination on trained immunity: impact on COVID-19. BioRXiv doi: https://doi.org/10.1101/2020.10.14.20212498
Every year, influenza causes 290.000 to 650.000 deaths worldwide and vaccination is encouraged to prevent infection in high-risk individuals. Interestingly, cross-protective effects of vaccination against heterologous infections have been reported, and long-term boosting of innate immunity (also termed trained immunity) has been proposed as the underlying mechanism. Several epidemiological studies also suggested cross-protection between influenza vaccination and COVID-19 during the current pandemic. However, the mechanism behind such an effect is unknown. Using an established in-vitro model of trained immunity, we demonstrate that the quadrivalent inactivated influenza vaccine used in the Netherlands in the 2019-2020 influenza season can induce a trained immunity response, including an improvement of cytokine responses after stimulation of human immune cells with SARS-CoV-2. In addition, we found that SARS-CoV-2 infection was less common among Dutch hospital employees who had received influenza vaccination during the 2019/2020 winter season (RR = 0.61 (95% CI, 0.4585 – 0.8195, P = 0.001). In conclusion, a quadrivalent inactivated influenza vaccine can induce trained immunity responses against SARS-CoV-2, which may result in relative protection against COVID-19. These data, coupled with similar recent independent reports, argue for a beneficial effect of influenza vaccination against influenza as well as COVID-19, and suggests its effective deployment in the 2020-2021 influenza season to protect against both infections.