Having an antibody response is associated with protection from re infection Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Lumley SF et al. N Eng J Med DOI: 10.1056/NEJMoa2034545 BACKGROUND: The relationship between the presence of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the risk of subsequent reinfection remains unclear. METHODS: We...
The Oxford vaccine…I mean COVID-19 vaccine zeneca
Want a read The Oxford University/AstraZeneca vaccine has been approved for use for people 18 years or older and consists of two doses, with the second dose administered 4-12 weeks after the first dose. The transportation and storage requirements for this vaccine mean that it needs to be kept at temperatures of 2C to 8C, which is similar to a conventional fridge for up to six months and can be...
Blurb about COVID-19 Vaccines from UK Government
If you want to read about the two approved vaccines in the UK. They have not tested people taking immunomodulatory agents and are covering themselves by saying that they may not work totally effectively. This is why we need to collect the data UK Public UK Public Pfizer BioNTech It says “Talk to your doctor, pharmacist or nurse before you are given the vaccine if you have: a weakened immune...
Bed to 5km Challenge
It’s officially over! Prof G and Dr Ruth, paired-up this afternoon for a socially-distanced 5-km walk around Brockwell Park in South London. This officially completes Prof G’s ‘Bed to 5-km Challenge’ to help raise money for Dr Ruth’s and Dr Angray’s COVID-19 antibody study. The good news is that the Barts-MS team through ‘Prof G’s virtual NYC...
BartsMS COVID-19 vaccine advice
Following on from ProfG’s vaccine-post yesterday, I’ve now uploaded the vaccine advice BartsMS have produced for pwMS. As always with such documents, it is going to age rather quickly as new evidence emerges. COVID-vaccine-guidance-in-MS_final_1.3 I support ProfG’s view 100% that you should have the vaccine, unless there are specific contra-indications. I also agree that...
Food for thought
The gastrointestinal tract (image taken from The Conversation) You may not think much of your gut, which in most peoples mind is simply one giant hosepipe from start to finish. But, this week after eating something quite oily, I was painfully made aware of my gut’s existence. The gut from an energy and metabolic point of view is a very important organ, and without it you would simply be a...
Variations in neurofilament
Neurofilament is fast becoming a new biomarker for MS, but ths research suggests that there is variant form one time point to another. Variations in consecutive serum neurofilament light levels in healthy controls and multiple sclerosis patients.Bridel C, Verberk IMW, Heijst JJA, Killestein J, Teunissen CE.Mult Scler Relat Disord. 2020 ;47:102666 Background Neurofilament light is a neuronal...
A leopard can’t change its spots or is it just common sense
Biological Significance of Anti–SARS-CoV-2 AntibodiesLessons Learned From Progressive Multifocal Leukoencephalopathy Navid Manouchehri, Lawrence Steinman, Olaf Stuve. Neuology N2. DOI: Objective To discuss the pathogenic and diagnostic relevance of cellular and humoral immune responses against severe acute respiratory syndrome novel coronavirus (SARS-COV-2) and...
Mice full of human cells react well to myelin antigens
Attenuated immune control of Epstein-Barr virus in humanized mice is associated with the multiple sclerosis risk factor HLA-DR15.Zdimerova H, Murer A, Engelmann C, Raykova A, Deng Y, Gujer C, Rühl J, McHugh D, Caduff N, Naghavian R, Pezzino G, Capaul R, Zbinden A, Ferlazzo G, Lünemann JD, Martin R, Chatterjee B, Münz C.Eur J Immunol. 2020 Sep 19. doi: 10.1002/eji.202048655. Online ahead of print...
Although this year has been SH1…Hope you have a happy Feastive period with your loved ones….or yourself, if you are a Victim of the BoJo Grinch
Let’s face it…It has been a SH1 year…in more ways than I can explain at the moment. MS-research and our live’s have been put on hold. From the selfish prospective, hopefully ProfG will make a complete recovery after his accident and he will be back in the near future. We have sent him a year’s supply of razors, as it seems he has set the challenge to be ZZ...