As vaccines start to arrive on these and other shores, it is only a matter of time before they reach you.
The NMSS has created a vaccination “Task Force”. The last time I heard that term was when I was a young mouse at Uni and I thought I was off to the Falklands on a state-sponsored trip c/o The Iron Lady :-(. Luckily conscription did not occur.
However, there are some simple questions: –
1-4. Do people with MS make T and B cell responses to the COVID-19 vaccine and how long do they last.
This is probably going to be of limited difference to the age-matched general public.
5. However, the answer we are less sure about is about for people on DMT. . So hopefully the US task force can give us the answer.
6. When is the optimum time to vaccinate?
The answer is before you start DMT, but that is not the question we need answers to. Importantly, the answer will depend on which DMT you are taking.
Please help ProfG and the lovely Kit and Pom support the infrastructure that can be used to get this answered.
P.S. We would be happy to accept Corportate sponsorship/donations. Why not build this into your safety monitoring.
FYI. Our lot at Queen Mary have been a real tight-fisted bunch, I think the article of ProfG’s accident in the College News letter raised about five quid (only joking). Maybe they felt that “Captain Tom” had done this form of “ice bucket challenge” already. So ProfG should not have got run-over to raise a few bob:-) for research. Anyway thank you all so much, for your support. It is greatly appreciated.
As you know the whole publishing approach has gone out of the window and we (Scientific Community) are putting stuff in the public domain before it has been reviewed.
Therefore, so you know …we…yep the Royal we…i.e. Dr Angry has made a COVID-19 antibody test based on shrimp vomit:-) …oK that is only part of the magic….We can spot if you have made an antibody response and we (the Royal we) have found that we can do a number of tests off a single drop of blood….yep we use about 2 and a bit microlitre in an assay, so that is about 2millionth of a litre. Any less and it is difficult to dispense. For your information a drop of blood is about 60 microlitre. We can collect this on absorbant paper (Whatman 903). Meaning you don’t have to come into Hospital to give blood and we don’t have to employ anyone to take blood, which adds to the cost and time taken to process the sample and importantly we dont have to buy and fill up a freezer to store all the bloods.
Once the card dries the antibodies contained within the blood spot are remarkably stable. We can get them out of a dried blood spot from a finger prick. We mix the blood (or reconstute a dried blood spot) with chemicals that destroys viruses not just SARS-CoV-2 but hepatitits B and others so it is safe to work with, without need for special equipment. . We can punch the blood spot into a tube to do the assay.
If you have been willing to participate and have been sent the card and the kit and the consent form from DrRuth and team. I would say one good spot is better than five tiny spots and don’t worry if one spot is not as good as the others and we only need one spot. These have been done on our local population….its a long story…. but with ProfGs and Kit’s effort I am sure we can go further afield, as was originally planned before the Spanners started to fly If you are a neuro who is interested contact DrRuth.
I had a go and was pretty rubbish at getting any blood out. If you get your hand after finger prick below your heart the blood flows better, if you can stand up after the needle prick it helps the flow and remember add some pressure to the finger prick and raise your hand above the heart to stem the blood flow.
Did you know that President Donald Trump was auditioning for a video on how to do a blood spot. However, he kept on getting it wrong….Too much conditioning to putting pressure on the index figure.
We got a spot of blood from two related people, one of whom had a positive COVID-19 swab test 5 months before the blood spot was taken. The blood spot was kept at room temperature for a few months before the assay was done. One gave a response of about 25,000 light units, the other was well over 6 million light units. Can you guess which one had COVID-19 and gave the positive swab result. Now you dont have to have our assay to do this, but some just won’t do because they do not quantitate the response properly and some are not that sensitive.
The clock is ticking because we want to get this started before people get vaccinated. The baseline is important. The UK and now USA and Canada have given emergency approval for an RNA vaccine, the EU will shorly follow. No doubt some National Approaches will monitor people using serum collected blood by puncturing veins. This will work but it is more labour, however we also view the blood spots and COVID-19 as a tool to develop something more useful for pwMS or other indications .
If you are interested in reading about the first COVID-19 vaccine approved in USA/UK here is the paper (click here).
The main side effect was injection site reactions but the local reactions did not increase after the second dose. No participant reported a grade 4 (Severe) local reaction. In general, local reactions were mostly mild-to-moderate in severity and resolved within 1 to 2 days.
This RNA vaccine may provide some early protection, starting 12 days after the first dose. The vaccine efficacy between the first and second doses was 52% (95% credible interval 29.5% to 68.4%), and Seven or more days after the second dose, vaccine efficacy then rose to 95% (90.3% to 97.6%).
You may have heard that some people had allergies, perhaps we can look at this to see if they are certain types of antibodies before the infusions
If you want to read the data from the most advanced adenoviral study then click here. It shows that when big pharma run the show things run more clockwork like. I hate experiments where you start with a big group and then decide to do everything and slice the experiment into little pieces, but I guess the take home message is that the double dose offers about 60% protection.