Archive2021

The writing was on the wall for fingolimod…But it was written in invisible ink:-( The destiny of vaccination responses.

When I was an scientific amoeba  beta interferon came along and worked in MS then we had a sea of papers in EAE telling us that beta interferon was immunomodulatory in mice. I thought who cares at that point as you know the answer in humans, why waste animals? Also you could see it was rather rubbish in animals except in the study that used human beta interferons in mice….They should have...

#MSCOVID19

COVID-19 vaccines and multiple sclerosis disease-modifying therapies Gavin Giovannoni,Christopher H. Hawkes,Jeannette Lechner-Scott,Michael Levy,E. Ann Yeh,David Baker MSARDS DOI: Much more evidence has emerged since our first editorial in April 2020 on the use of multiple sclerosis (MS) disease-modifying therapies (DMTs) during the pandemic (Giovannoni et al., 2020) and a further publication in...

Splosh, Splosh Splosh, the drips are increasing Vaccination and fingolimod and anti CD20 are like oil and water…Not mixing

Today we have the first interim analysis of vaccination data from Italy they have looked at over 700 people on their way to studying 2000 people. So I think we can safely say in terms of anti-CD20 and fingolimod, that they are problem children in terms of the antibody response Effect of SARS-CoV-2 mRNA Vaccination in MS Patients Treated With Disease Modifying Therapies. Sormani et al. Background:...

Having Two Pricks. You are not alone!

No nothing to do with Lizards:-) but the Jabs…..Well done MS-Britain you want the Jab…but let’s finish the job/jab Highlights •94.4% of people with multiple sclerosis (MS) would accept a COVID-19 vaccine•People of increasing age and influenza vaccinations were more likely to accept•Safety concerns and lack of information were top reasons for not getting a vaccine•51.7% of people...

COVID19..Drip, Drip Drip….B cell repopulation determines the ability to give antibody response after COVID-19 vaccination

Learning from other conditions is useful. As there are more people with rheumatoid arthritis than MS we will see alot of anti-CD20 papers with rituximab. There will be subtle differences compared to ocrelizumab. So when you read the paper that says the vaccine response to anti-CD20 is unknown….it’s not its getting less unknown by the day. If you are taking ocrelizumab you should...

Off-Label Use of Drugs

I give you something that is not MS COVID (p.s. thats below). Laurson-Doube J, Rijke N, Helme A, Baneke P, Banwell B, Viswanathan S, Hemmer B, Yamout B. Ethical use of off-label disease-modifying therapies for multiple sclerosis. Mult Scler. 2021 Jul 26:13524585211030207. doi: 10.1177/13524585211030207. Epub ahead of print. PMID: 34304636 Background: Off-label disease-modifying therapies...

SIZOMUS randomized clinical trial is on the roll

SIZOMUS anti-plasma cell RCT I’m happy to notify that SIZOMUS (Safety of IxaZOmib targeting plasma cells in Multiple Sclerosis) is re-commencing after MHRA approval. This follows a pre-planned interim safety analysis. MHRA stands for Medicines & Healthcare products Regulatory Agency and without their say so this trial would not have been able to proceed. The Medicines and...

#MSCOVID19

Sormani, MP et al. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context. SSRN:  Background: It is unclear how multiple sclerosis (MS) affects the severity of Covid-19. Methods: Hospitalization, Intensive Care Unit (ICU) admission and death after Covid-19 diagnosis of 1362 MS patients were compared to the age and sex-matched Italian population in a retrospective...

Vaccine Safety in MS

The safety issues for MS are similar to the the issues of the general population but one issue to be aware of is Uhthoffs phenomenenon. This is where an increase in temperature can cause demyelinated nerves to transiently stop firing. One of the side effects of vaccines can be fever and so this will raise temperature and so could cause some symptoms to transiently worsen. However, I am sure you...

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