Archive2021

Guest-post from an ocrelizumaber

I uploaded a video to theMSguide.com a few days ago talking about my concerns as an ocrelizumab patient and how the potential lack of Covid vaccine response stood to impact my life. I am five full infusions into this DMT and the fact that it appears to severely impact the ability to generate a meaningful immune response after a Covid-19 jab is administered is no fault of anybody or anything. It...

How flipped is your consultant?

Barts-MS rose-tinted-odometer: ★★ If you don’t measure it you can’t change it.  The fact that the UK was performing so poorly relative to other EU countries on the EMSP’s MS barometer was one of the reasons why I got into MS politics and helped put together the ‘Brain Health: Time Matters’ policy document.  In 2015, despite being the second wealthiest nation in Europe, the UK was in the...

Vaccine Trumpism for President!

A pneumonia might not sound like something you necessarily want to avoid in life, or not something that ‘coughs’ you awake. However, outcome data on pneumonia in non-hospitalised individuals do indicate it’s not a benign condition. A large study in Germany showed a 30-day mortality of 6.3%. Obviously, this was mainly driven by age (mortality was 2.2% below 65 years old) and nursing home status...

Two, four, six, eight, who do you appreciate?

Barts-MS rose-tinted-odometer: ★ This week I was asked by two patients independently of each other who had delayed access to treatment if this could explain why they now have secondary progressive MS. In parallel, I had a meeting with a friend yesterday, who was the primary driver of the 21-year interferon-beta follow-up survival study (see below), who said that to him this was the most...

An existential crisis

Barts-MS rose-tinted-odometer: zero-★s The Barts-MS blog is having yet another existential crisis. Have you been to Speakers’ Corner on the Northeast point of Hyde Park in London? If you haven’t I would recommend visiting and spending an hour or so watching and listening. Speakers’ Corner is where anyone, who is anyone, can stand on a soapbox and speak their mind on any topic that takes their...

RUN SIZOMUS RUN!

Mama Always Said, Life Was a Box of Chocolates. You Never Know What You’re Gonna Get – Forrest Gump, 1994  A few years back Prof G, whilst talking about MS at a conference was approached by Takeda Pharmaceuticals on whether we would be interested in targeting plasma cells; probably one of the last frontiers in MS. The ideas started spinning from there. Roll forward a few years, after...

#MSCOVID19: T-cell response on ocrelizumab

Barts-MS rose-tinted-odometer: ★★★★★ As you know the vast majority of pwMS on anti-CD20 therapy who get COVID-19 or for that matter any other viral infection recover. In other words, their immune systems work despite blunted or absent B-cell or antibody responses. This study presented yesterday at the AAN meeting confirms that ocrelizumab-treated patients who get COVID-19 have good robust T-cell...

AAN2021 T cell response in COVID-19 infected people treated with CD20 antibodies.

As profG has made the post here is the data First up we have Asplund Högelin, Klara and Ruffin, Nicolas and Pin, Elisa and Månberg, Anna and Hober, Sophia and Gafvelin, Guro and Grönlund, Hans and Nilsson, Peter and Khademi, Mohsen and Olsson, Tomas and Piehl, Fredrik and Al Nimer, Faiez, Development of Humoral and Cellular Immunological Memory Against SARS-CoV-2 Despite B-Cell Depleting...

The Star-MS trial: to be HSCTed or not

Barts-MS rose-tinted-odometer: ★★★ There is little doubt in my mind that HSCT is the most effective DMT we have for treating MS. The latter is based on NEDA (no evident disease activity) rates post-HSCT and brain volume loss data after year one. HSCT appears to put the majority of treated patients into long-term remission and normalises end-organ damage as measured by brain volume loss. In...

AAN 2021. Ocrelizumab overdosing?

Why was ADIOS a no brainer?…..Perhaps because it was going to work! ProfG with a non-fully functioning, non-productive brain can see the logic of ADIOS, hopefully you can see the value of ADIOS, but can other Neuros see it? In some instances I’m afraid not…..I did a debate to young neuros and had my ass-kicked by my opponent. I gave them more data than you can shake a stick at...

Translate

Categories

Recent Posts

Recent Comments

Archives