ArchiveJanuary 2021

Alemtuzumab and HSCT associated with Thyroid autoimmunity

I guess we can say this real life data says what we already know. Sorry too busy to do aninteresting post Alping P, Burman J, Lycke J, Frisell T, Piehl F. Safety of Alemtuzumab and Autologous Hematopoietic Stem Cell Transplantation Compared to Non-induction Therapies for Multiple Sclerosis. Neurology. 2021 Jan 29:10.1212/WNL.0000000000011545. doi: 10.1212/WNL.0000000000011545 Objective: To...

#MSCOVID19: vaccine hesitancy

Barts-MS rose-tinted-odometer: ★★★ She is in her early thirties and is a first-generation ethnic minority immigrant to the UK. She was diagnosed as having MS 6 months ago after presenting with optic neuritis and a subsequent spinal cord syndrome. She is due to start on ocrelizumab in the next few weeks, but we want to delay her start until she has her first dose of one of the COVID-19 vaccines...

Synapses and macrophages are useful targets for Mice

Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltrán E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M.Nat Neurosci. 2021...

BartsMS Filmweek Part 5

Part 5

Oral Cladribine and IRT

CoI: These videos were sponsored by Merck and for regulatory purposes this has to be disclosed. However, this was collaborative and the content was generated by a video production company following generation of a story board created by them and importantly ProfK and B and BartsMS PPI members acting as consultants via Queen Mary University of London.

#MSCOVID19: backing another winner

Good news! Another UK-backed COVID-19 vaccine, developed by Novavax, proves to be a winner with a point estimate of vaccine efficacy of 89.3% and no cases of severe COVID-19 in those who received the actual vaccine. The vaccine also works against the UK and South African variants of the virus. This vaccine is important because it is based on using a recombinant form of the spike protein produced...

HSCT Time

As ever I am not going to comment on this paper as it is bait for the Zealots but as as you can see the results are encouraging and they have reduced the death rate. It is highly un-optimised as you can see people underwent the procedure at EDSS9. Further evidence that relapsing disease is immune mediated Long-Term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis...

#MSCOVID19 Vaccine and Age

There is a suggestion in the media that giving the Astrazeneca vaccine to the over 65s doesn’t work very well and so some Continental Europeans won’t be using it…So Good news for the Youngers who are less at risk as there will be more to go round, but nothing for the retirees… Seems the New Headline is : No work No vaccine, sadly if means less options for some of our...

BartsMS Filmweek part 4

Part 4

MS treatments and the Immune Systm

CoI: These videos were sponsored by Merck and for regulatory purposes this has to be disclosed. However, this was collaborative and the content was generated by a video production company following generation of a story board created by them and importantly ProfK and B and BartsMS PPI members acting as consultants via Queen Mary University of London.

#T4TD: pneumonia

Barts-MS rose-tinted-odometer: zero-stars #T4TD (thought for the day) How bad is your breathing and lung function? Every year a few of our patients with advanced MS die. During the first COVID-19 lockdown I received an email from the husband of one of my patients I had been looking after for over a decade. Thankfully she died peacefully in her sleep. Her MS had affected her swallowing to such an...

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