ArchiveJanuary 2021

Alemtuzumab and HSCT associated with Thyroid autoimmunity

I guess we can say this real life data says what we already know. Sorry too busy to do aninteresting post Alping P, Burman J, Lycke J, Frisell T, Piehl F. Safety of Alemtuzumab and Autologous Hematopoietic Stem Cell Transplantation Compared to Non-induction Therapies for Multiple Sclerosis. Neurology. 2021 Jan 29:10.1212/WNL.0000000000011545. doi: 10.1212/WNL.0000000000011545 Objective: To...

Synapses and macrophages are useful targets for Mice

Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltrán E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M.Nat Neurosci. 2021...

BartsMS Filmweek Part 5

Part 5

Oral Cladribine and IRT

CoI: These videos were sponsored by Merck and for regulatory purposes this has to be disclosed. However, this was collaborative and the content was generated by a video production company following generation of a story board created by them and importantly ProfK and B and BartsMS PPI members acting as consultants via Queen Mary University of London.

HSCT Time

As ever I am not going to comment on this paper as it is bait for the Zealots but as as you can see the results are encouraging and they have reduced the death rate. It is highly un-optimised as you can see people underwent the procedure at EDSS9. Further evidence that relapsing disease is immune mediated Long-Term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis...

#MSCOVID19 Vaccine and Age

There is a suggestion in the media that giving the Astrazeneca vaccine to the over 65s doesn’t work very well and so some Continental Europeans won’t be using it…So Good news for the Youngers who are less at risk as there will be more to go round, but nothing for the retirees… Seems the New Headline is : No work No vaccine, sadly if means less options for some of our...

BartsMS Filmweek part 4

Part 4

MS treatments and the Immune Systm

CoI: These videos were sponsored by Merck and for regulatory purposes this has to be disclosed. However, this was collaborative and the content was generated by a video production company following generation of a story board created by them and importantly ProfK and B and BartsMS PPI members acting as consultants via Queen Mary University of London.

Super-scientific. The Godfathers of B cells think it is all T cells

This is a hardcore read for those interested. There is quite alot of hardcore science to digest here and in the end result the idea is that B cells are acting as antigen presenting cells for T cells. I guess therefore that we need to see the effect of T cell immunotherapy in the modern era where people are not scared of T cell depletion Antigen Presentation by B Cells...

BartsMS Filmweek Part 3

Part 3

Immune System and Infection

CoI: These videos were sponsored by Merck and for regulatory purposes this has to be disclosed. However, this was collaborative and the content was generated by a video production company following generation of a story board created by them and importantly ProfK and B and BartsMS PPI members acting as consultants via Queen Mary University of London.

Role reversal. You have been the guinea pigs for experiments by academics. Now those Healthcare workers are guinea pigs for you!! #MSCOVID19

The vaccination against SARS-CoV-2 is seen as a great hope to get back to some form of normality. Reducing the pool of people who can be infected is key to this aim. I am not sure we are going to achieve this as it seem there are too many people who don’t care and don’t want to do their bit for Society. There is a strong anti-Vax movement and this may help ensure that this virus hangs...

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