What drives progressive MS and what is the solution? You get the views of ProfG but this is just one opinion and there are others. If you like lab Lessons have a read of this review it gives a different take on what is going on and what the solutions may be
It is an opinion and not necessarility the right opinion and not necessarilly the same opinion as me but it is someone elses opinion.
What do you think. They say
One suggestion that brain damage is driven by inflammatory processes similar to those observed during RRMS; but that during progressive disease stages, a microenvironment is created within the CNS favouring homing and retention of inflammatory cells, ultimately causing disease-modifying therapies to become largely ineffective (Frischer et al., 2009).
Secondly, multiple sclerosis starts out as an inflammatory disease, but after several years, a neurodegenerative process independent of inflammatory responses becomes the key mechanism responsible for
disease progression (Meuth et al., 2008).
Finally, multiple sclerosis could primarily be a neurodegenerative disease,
with inflammation occurring as a secondary response, amplifying progressive states (Barnett and Prineas, 2004; Kassmann et al., 2007). Clearly these different mechanisms are not mutually exclusive and could act together.
If the answer is EAE…What is the question?