The development of COVID-19 and the rapid way that RNA vaccines have been developed means that you have a rapid way of developing vaccines against your viruses of choice. So which virus do you want to get rid off…The ones that cause warts
Epstein Barr Virus?
Well ProfGs wish is their command, maybe he can convince them to do a glandular fever trial
Well it is is the pipeline mrNA 1189
EBV infects virtually everybody and so do cyclomegalovirus CMV and there it is mRNA1647/ BioNTech are going after HIV, Flu.
However what about JC virus.
It infects about 50% of us….but here now comes the problem…We made an immune response against it and keep it in check. So how do you get it on the agenda
It can hide from the immune system and pops out when people become immunosuppressed, but get rid of JCVirus and natalizumab and some of the other MS drugs like dimethyl fumarate and fingolimod become just that bit safer. Natalizumab with a minor risk of PML
Will Biogen talk to their Cambridge neighbours (Moderna) have a coffee and do a deal? I can see the trials design but the big question for vaccines is can it get rid of an existing infection and this is where vaccines struggle. But to keep someone on tysabri JC negative would be good. Then it gives you a problem and you have to make a new test as being antibody positive means you have have been infected with the JC virus.