#MSCOVID19 paper avalanche


Today there are more papers published on COVID-19 (in one year) than the whole of the MS literature

Most scientists will ask did they get one?…..one what?…..a COVID-19 paper. You seem to be able to write any old SH1 and get one. Who would have thought that there would be over 2,000 papers on face masks. Only last week there was one in PeeNAS saying infected people should wear them as well as susceptible people…….Duh!

MS papers continue to appear and the next wave will be response to vaccines. Here is a review of cases in MS

Möhn N, Konen FF, Pul R, Kleinschnitz C, Prüss H, Witte T, Stangel M, Skripuletz T. Experience in Multiple Sclerosis Patients with COVID-19 and Disease-Modifying Therapies: A Review of 873 Published Cases. J Clin Med. 2020 ;9(12):4067.

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a challenge for all participants in the healthcare system. At the beginning of the pandemic, many physicians asked themselves what risk their patients, especially those with chronic diseases, were exposed to. We present an overview of all patients with multiple sclerosis (MS) and SARS-CoV-2 infection published in the literature so far. In total, there are publications on 873 SARS-CoV-2 positive MS patients and information on the outcome can be given for 700 patients. With regard to the different disease modifying therapies (DMTs), by far the most cases were described under anti-CD20 treatment (n = 317). The mortality rate of all MS patients was 4% and a further 3% required invasive or non-invasive ventilation. When looking at the severe and fatal cases, it is particularly noticeable that patients without DMTs, with previous cardiovascular diseases, or with a severe degree of disability are at risk. Immunosuppressive therapy itself does not appear to be a substantial risk factor. Rather, it is reasonable to assume that the therapies could be protective, either directly, by mitigating the cytokine storm, or indirectly, by reducing the disease activity of MS.

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Results to October 2020

The outcome was

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  • Useful, although my outcome of interest is not whether I would die of covid, but whether covid causes relapse/disease activity/worsening of ms symptoms. In addition, symptoms of long covid sounds relatively familiar and by default are worrying, thus I’d be interested to know if ms patients are more vulnerable to these long term problems than the general populace…

    • There have been thousands of people with ms infected with covid and add to that people with other immune conditions. There is no evidence of worsening. OK never.say never.

  • Thanks MD – This is very informative and gives a slight reassurance too!

    I like your choice in colours for the graphs/charts – for pwMS and in particular my dodgy eyes, they stand out well and I don’t have to enlarge the screen 🙂

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