As you may now the UK is in abit of a pickle at the moment as there more COVID-19 around than Zombies in Zombieland. It has similarities, go to the Shopping Mall and you are surrounded by Zombies (not wearing masks and no understanding what socially distancing is) that may kill you.
Sorry I can’t give a fraction of Great British Public alot of credit for understanding this one, you just have to watch the news or go to a supermarket (If they can’t wear a mask….they should be shielding). Perhaps, this is why there are so many parking crashes…. when the person guiding you into the space says that you have 12 inches (30cm) pf space when it is only 6 inches (15cm).
Wonder where that idea comes from? Go ask your Dad:-)
In Zombieland you have to get bitten and you have the pleasure of wiping out the undead, however here in Covidland, you just get breathed on and is sometimes a slow miserable death for someones mum, dad, grandad and gran. Lock downs cannot go on forever and vaccination is one of the best ways out of this.
“I don’t need the vaccine” as I’m young and healthy,(yep as virus reactor)…but tell that to the young and old who are not so healthy or those that have not done so well. In 1914 the young were probably told those “bullets won’t kill you, off you go and charge that machine gun”. But this view is not quite right and have to tell that to millions of soliders how were not so invincible. However, who would have thought that the real killer from the First World war was not the bullet, but the Flu virus that the solider, possibly from the US, took to Europe and killed 50 million people including my great nan.
The best way to get rid of a virus quickly is to have a strong immune response so that it is destroyed before you can pass it on or before it has time to mutate into something that the immune response can’t get rid of.
This may be important as you may eventually get a variant that you do not have not enough immunity to and the cycle repeats itself. It has been suggested that new variant developed in someone who had been immunosuppressed and the virus had hung around and mutated and mutated such that it was more infective and perhaps abit less sensitive to the immune response generated by vaccines to the original virus strain.
Will we get an escape mutant that the vacccines don’t work on, then we are back to square one. The virus will be around forever and eventually the youth become the oldies and get all those co-morbidities and now it is their turn for death destruction and COVID-long. I speak to deaf ears, who may only care if they find out that they can’t go abroad to watch the Euros as their name is on the anti-Vaxxer list.
As the SH1 hits the fan in ZombieLand UK, desparate measures are being put in place, the vaccines that we have developed are going to used in a way they have not been envisioned to be used. The view of protecting people as quick as possible. The vaccines we have are going to be given up to 12 weeks apart.
So let’s have look at one dose what happens. First the Oxford Astrazeneca vaccine.
I will start you off with the Ebola vaccine which uses the basic viral contrstuct as the covid vaccine, This was designed for a single shot.
Here within one month 71% made a response to the vaccine but the SARS-COV2 vaccine is better. Within 28 days more than 98% of people make an antibody response of one dose.
This information is from the information within the blog post
As you can see (in yellow) within 14 days of the first dose there was an antibody response that was evident at 8 weeks (day 56)
and there was a T cell response
A maximum T cell response was evident within 14 days of the first dose and the second dose did not add more.
Although the dose schedule we thought would occur was day week 0 second dose week 4 but could be up to week 12. In one of the vaccine trials 53·2% of 2741 participants a second dose at least 12 weeks after the first (50% got second dose by 84 days, (25% by 77days and 75% got the dose by 91 days =13 weeks) and 0·8% received a second dose within 8 weeks of the first. The average interval between doses for the standard double dose group was 69 days (50–86days). This is probably the reason 12 weeks was selected by this ranged from 4 to 26 weeks. Therefore in the trials some people got the second dose up to 6.5 months after the first.
Therefore if you are dosed 2-4 weeks before treatment if you have cells that can respond they will have responded. The second dose boosts the levels of antibody
If you have been previously infected you may make an even better responses after the first dose the level of antibody went up alot (GMT=175,120.84 [N=28; 95% CI: 120,096.9 to 255,354.8] of one dose
Now to the Pfizer/BioNTech vaccine and things here are clearer because the trials were not quite as “Pick & Mix” as the Oxford-run DB trial. They will have the data on how quick and how long on dose of vaccine worked but you can see that it is not so quick acting in the graph below at day 21 they would have had one dose waiting for the second doses, so the antibody response was not strong
However that and a T cell response must bedoing something good as
This is hard yo work out as there is not supportive information but lets look at the Dolly/Moderna vaccine
No-one with any of the vaccines have been hospitalised and died after having any vaccine and they are no doubt less infective as a result of being vaccinated. One dose maybe all that you need to get enough protection but clearly two will make you less infective.
CoI None relevant