You can have loads of ideas but you can’t do all the science on the planet, but it is nice to see an idea come true. Since the COVID-19 pandemic arrived
Now what do I mean Sod the COVID vaccine, well of course I dont mean don’t take it if you are offered it. But what is the vaccine going to do? Hopefully, it is going to stop you getting symptomaic infected so that you do not pass on the virus. But if it fails tha,t it is going to stop you getting severe covid 19 and having the virus for so long and it should stop the virus from killing you….OK abit amateur dramatic here.
However, when the COVID-19 pandemic arrived we went T and B cell made and the vaccine focuses your view to the T and B cells, but we suggested that your best defence against the virus was you innate immune system notably the macrophages.
The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID–19 pandemic.Baker D, Amor S, Kang AS, Schmierer K, Giovannoni G.
This was because in many people they get rid of the virus before the lymphocytes appear. This in part explains why the worst feature for having bad COVID-19 is age. Old people die and young people shrug the virus off without symptoms. Likewise, young people often shrug off an relapse whilst older people accumulate deficit. This is because as you get older you don’t repair as well and you turn into a wrinkly. The key to this is probably not the lymphocytes but the macrophage. To get repair you have to get the macrophages to clear up the debris and as they get older this aspect fails.
Now the boffs from Cambridge and elsewhere came up with the idea that you could turn back the aging clock with a diabetes drug called metformin. So if you mix the metformin with a myelin repair drug you get repair in an oldie mouse, so there are now planned trials to do this in MS. I am sure they will start as soon as COVID-19 is dealt with, but quite possibly if people dont take up the vaccine and we dont get rid of virus.
However if you put these ideas together the metformin is going to have benefit against covid-19 and indeed this is what we suggested
Innate immunity during SARS–CoV–2: evasion strategies and activation trigger hypoxia and vascular damage.Amor S, Fernández Blanco L, Baker D.
Now I am sure you have heard that diabetes is a risk factor for severe COVID-19 some of these people will take metformin to modulated glucose (sugar). It lowers your blood sugar levels by improving the way your body handles insulin. It’s usually prescribed for diabetes when diet and exercise alone have not been enough to control your blood sugar levels.
Crouse AB et al Metformin seu Is associated with reduced mortality in a diverse population with COVID-19 and diabetes. . Front. Endocrinol., 13 January 2021 | https://doi.org/10.3389/fendo.2020.600439 showed that taking metformin could reduce the risk of fatal COVID-19 by a third, so bring on the MS trials repair from MS and protection against COVID-19
The point of this post is to suggest that maybe we on a useful avenue for treatment. But we will will have to wait and see