Is there a #MSCOVID-19 Surge? How about the Zombie apocalypse? What about pregnancy?

I

You never know what the media may pick up and this is one that the “doom and gloomer”s may like. The authors suggest that as it has been suggested that MS may be caused by virus Therefore SARS-CoV-2 may cause a surge in MS and as JC virus in the brain is a problem with natalizumab, because SARS-CoV2 causes neurological problems, then you have to be concerned.

Although never say never….I will answer to the question in the title…..No!. Where is the evidence? Maybe I should written a paper to say SARS-CoV-2 is going to cause the Zombie Apocalypse, becuase it has been predicted by the Daily Express.

According to the Worldometer there have been over 100,000,000 cases (remember more people won’t have been tested) and we have had 20,000-60,000 people infected a day so there should a deluge of work for ProfG and ProfK. OK, I haven’t seen ProfG too much in the past few months, but I dont think it is because he has been busy diagnosing new cases. Likewise, I haven’t noticed reports of natalizumab-treated people having a terrible COVID-19 time although people taking natalizumab have been infected with the COVID-19 virus. Clearly there are neurological issues with SARS-CoV-2 but some of these are vascular issues as SARS-COV-2 cause bloot clots and in some of the post-mortem studies they cannot find the virus in the brain tissue.

Shalaby NM, Shehata HS. Could SARS-CoV-2 herald a surge of multiple sclerosis? Egypt J Neurol Psychiatr Neurosurg. 2021;57(1):22. doi: 10.1186/s41983-021-00277-5.

During the current COVID-19 pandemic, many queries are raised regarding its nature, outcome, and sequelae. This letter raises the concern of potential impact on increasing the incidence of multiple sclerosis whose pathology involves a possible viral aetiology. Besides, the potential neurotropism of the acute respiratory distress syndrome corona virus-2 (SARS-CoV-2), which is still not established, may raise concerns about the use of certain disease modifying therapies namely natalizumab.

However what about Pregnacy? Dr. Seheult tells us that there is increase risk of pre-term birth and mums to be had an increased risk of ICU admission. There is not much evidence of the influence of prenancy on vaccine efficacy, but vaccination did not seem to affect pregnancy. ProfG may make not a comment of vaccination and pregnancy.

If interested watch this

If you are really interested on the influence of pregnancy and COVID you can also listen to Dr Vicki Male, she worked with us at the Blizard Institute for a few weeks over the summer when she was a young school girl …..Boy this stuff aged you.

I am sure this makes MD2 very proud, as he has known Vikki since she was born.

Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study 

Francesca CrovettoFàtima CrispiElisa LlurbaRosalia PascalMarta LarroyaCristina TrillaMarta CamachoCarmen MedinaCarlota DobañoMaria Dolores Gomez-Roig… Show moreClinical Infectious Diseases, ciab104, https://doi.org/10.1093/cid/ciab104

The overall rate of pregnancy complications in women with SARS-CoV-2 infection was similar to non-infected women. However, symptomatic COVID-19 was associated with modest increases in preterm delivery and intrapartum fetal distress.

About the author

MouseDoctor

7 comments

Leave a Reply to TROLL Cancel reply

  • Dear David,

    Following our zoom meeting last Wednesday, I attach my note of our discussion about your performance in 2020. You may think my assessment has been harsh, but I think there is a need for both honesty and clarity. I am, of course, happy to discuss any of the points raised in my note.

    Regards

    TROLL

    Performance assessment for 2020

    – The global pandemic has been challenging for all members of Team G.
    – DB accepted that he had done little MS research during 2020 as he had been side tracked by issues related to Covid 19.
    – DB has continued to keep the Barts MS Blog alive, but the vast majority of his posts have been about Covid 19 and not MS research.
    – During 2020, with pubs shut for most of the year, DB had plenty of time to write up research papers and trial results – he did not do so.
    – I instructed DB to get Covid 19 ready ie lose weight, exercise and stop drinking. He ignored all my advice.
    – At the start of 2020 I gave DB a year to definitively answer the question “is MS a T cell or B cell disease?”. He made no headway on this issue.
    – A number of the rodents used by DB in his research looked underfed and many of the cages had not been properly cleaned. I raised this with DB during the year, but he failed to act on my instructions.

    Overall, DB’s performance grade for 2020 is ‘D’. I hope that DB takes on board my suggestions for improvement which I highlighted during our discussion. He needs to focus on MS research and not “go off track” and focus on non MS topics. Unless DB can start producing meaningful and insightful MS research papers, I will be forced to consult senior management to discuss DB’s future.

    PS DB is a friend as well as a colleague and was very supportive following my accident.

    • Dear TROLL
      – DB accepted that he had done little MS research during 2020 as he had been side tracked by issues related to Covid 19.

      In contrast to your allegation, plenty of MS research has been done, and whilst you are correct the number of EAE studies have been curtailed this is not due to COVID-19. Importantly this would be consistent with that requested by the management of QMUL to stop long-term animal experiments. This was not of major impact as the number of EAE experiments have been curtailed for other reasons unrelated to COVID-19.
      EAE experiments 2020 = 0, 2019 = 1, 2018 = 0.

      The number of MS papers have not been curtailed and the impact of COVID-19 on MS and vice vera is of paramount importance, given the knee-jerk reaction of some associations including the ABN.

      We can be pleased that ProfB created the concept of “vaccine readiness”, provided the first published insight into vaccine responses to ocrelizumab and essentially the first science based assessment of risk of DMT for COVID-19. We are pleased that ProfB participated in many educational COVID-related activities for neurologists in the UK and elsewhere around the Virtual World during 2020, including doing face to face teaching

      – DB has continued to keep the Barts MS Blog alive, but the vast majority of his posts have been about Covid 19 and not MS research.

      Indeed this was kept alive!. The posts were selected from MS research published. As the blog has been running for a number of years and much has been reported previously. COVID-19 related to our MS research. ACTRIMS, EAN, AAN meeting were covered single handedly.

      – During 2020, with pubs shut for most of the year, DB had plenty of time to write up research papers and trial results – he did not do so.

      You are wrong papers have been written up and others have been submitted (currently 5 submitted and others circulating).

      DB. 16 papers were published (First author 4)
      David Hafler Yale: 3 papers (first author 0)
      Larry Steinman Stanford: 3 papers (First author 0)
      Alasdair Coles Cambridge : 14 papers (First author 0)

      Additional papers will be written up for the next REF cycle starting 2021

      – I instructed DB to get Covid 19 ready ie lose weight, exercise and stop drinking. He ignored all my advice.

      None of your business, but again you are wrong

      – At the start of 2020 I gave DB a year to definitively answer the question “is MS a T cell or B cell disease?”. He made no headway on this issue.

      The answer to this was present at the beginning of the year. if you read.

      Data was provided that ocrelizumab efficacy better associates with memory B cell depletion and is the first data to show this. Published 2020.

      The first peer reviewed publication that ocrelizumab influneces hypogammaglobulinemia was published

      Access to the Alemtuzumab CARE-MS trials has been appled for granted and data is being analysed, Access to Roche Ocrelizumab trial has been applied for and granted and data is being analysed

      – A number of the rodents used by DB in his research looked underfed and many of the cages had not been properly cleaned. I raised this with DB during the year, but he failed to act on my instructions.

      Food and water are provided ad libitum (i.e. constantly available) and animals are checked daily every day 365 days a year. They have had veterinary care. These are regularly cleaned and are maintained according to UK law and therefore they get better attention an most peoples pets. There have been decidated staff doing this throughout lockdown.

      As you can imagine in response to Instituional requests animal numbers have been kept to a minimum and a Home Office return for 2020 involved 80 animals in total.

      -Overall, DB’s performance grade for 2020 is ‘D’. I hope that DB takes on board my suggestions for improvement which I highlighted during our discussion. He needs to focus on MS research and not “go off track” and focus on non MS topics.

      The COVID-19 related work will be channeled toward MS benefit when the laboratories are opened and have generated a remote test to monitor alemtuzumab anti drug responses.

      -Unless DB can start producing meaningful and insightful MS research papers, I will be forced to consult senior management to discuss DB’s future.

      Research relating to anti drug antibodies has gone from invention into clinical practise in one year as have the COVID-related initative. We are ready to go on two investigator led trials, most basic scientists never get anything changed for human benefit

      We have produced some videos for people who have a hard time reading and assimilating results

      P.S. If you want to troll get your facts straight otheriwse some people might think you are being a bit of a twanker.

      • DB (aka MD),

        Thank you for your detailed response to all the points raised in my note. On reflection I have been somewhat harsh). I have suffered this year with no MS conferences (therefore no airmiles), no lucrative lecture tours and no visits to my beloved country to check on my vineyards. Given this, I’m happy to upgrade your performance mark to a ‘C’. I was most grateful for the daily bed baths you provided to me following my accident (poor Mrs G is too screamish). So well done DB. I hope 2021 is more productive for all of us. I’m sure the two of us will rekindle our close working relationship once MD2 heads off back to the valley (leaks and daffodils have played havoc with the gut healthy of your mice / rats.

        Best wishes

        TROLL 😍😍😍

  • Dear GG
    I see that you like abit of horseplay (GG) but I have written to your Neurologist at Cambridge today to suggest a change in the anti-psychotics as your schizoprenia medications are clearly not working and hopefully my suggestions will get rid of your delusions also.

    Writing on blogs is not what I consider to be useful cognitive behavioural therapy and certainly not writing to the principal. Had you sent it to the right address perhaps ProfB would be put on Gardening leave and have some free time to give you a bit more behavioural training, as you are more or less neighbours. However, I have said to him that good manners are things that are taught by your parents and don’t need to be beaten into people. I have instructed David to investigate writing a new case report on alemtuzumab induced schizoprenia as a new autoimmune condition. I have asked for a blood sample to check for autoantibodies. However Sid, if I can call you Sid or do you want me to use your other name(s), please start taking the right medication. The other day I gave the definition of vexacious and perhaps when your medications start to act you can read a dictionary.

By MouseDoctor

Translate

Categories

Recent Posts

Recent Comments

Archives