ArchiveFebruary 2021

Now you see it, Now you don’t!

Obesity or high BMI and raised cholesterol have all been linked to an increased risk of multiple sclerosis. This is of particular concern in the Western world as obesity is fast becoming the single major determinant of an individuals health quotient. But, how far should we take this in MS? In a large study of 14802 MS cases and 26703 control, a group in San Francisco set about looking for a link...

Has pharma made a mistake with BTK inhibitors? Are microglia the good guys that shouldn’t be inhibited? Don’t worry. It’s all about Balance.

I’m a fan of “you can’t have it both ways” and it means that if you say this is good for that you can’t say the opposite is good for that too. So if you have a good guy you want to augment it for it to be good, but if you get rid of the good guy you would think it is going to be be bad. When you are a mechanistic science you sometimes don’t think about the...

Whilst CD20 antibody will probably blunt your anti-COVID19 antibody response. Probably fear not as remember T cells are the important ones. #MSCOVID19

In a rush go to the bottom to read T cells are the important ones. What? Am I having a bit of psychosis? I have been on a B cell crusade and have been saying that B cells are important for MS. ut now its T cells are important. Well yes and Yes. Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis.Baker D, Marta M, Pryce G, Giovannoni G, Schmierer K...

Rebound after treatment withdrawal says the important cells for relapse are…yep you got it!

ProfG always said the rebound that occurs after natalizumab was going to be one of the best ways to work out what are the important disease drivers in MS. Natalizumab is a brake for pathogenic cells entering the brain, Remove the brake and cells go in and trigger disease activation. Sadly by the time of thinking about this, strategies to stop rebound were developed and as we would switch...

HSCT vs. Alemtuzumab

So this is not a head to head efficacy study but says what we know alemtuzumab is associated with thyroid disease, HSCT is associated with more infections Safety of Alemtuzumab and Autologous Hematopoietic Stem Cell Transplantation Compared to Non-induction Therapies for Multiple SclerosisPeter Alping, Joachim Burman, Jan Lycke, Thomas Frisell, Fredrik PiehlNeurology Jan 2021, 10.1212/WNL...

COVID 19 in Scotland

Our friends from Scotland have reported on the the occurance of Scottish COVID-19 in people in the MS register. You don’t need me to explain this as it is clear in its message but have a read of the paper as you can read the reports of the three referees report on the merits of the post. Fernandes PM, O’Neill M, Kearns PKA, Pizzo S, Watters C, Baird S, MacDougall NJJ, Hunt DPJ. Impact...

Holiday aspirations COVID-19 style: The Mediterranean Diet

Do you need another alibi to daydream about travelling to Italy? Pompura et al. have given you the perfect ammunition. In short, they demonstrated that eating more olive oil might have a restorative effect on a crucial immune cell type in MS.   In the immune system, there are several types of T cells. One subtype that is potentially important in MS pathophysiology are the regulatory T cells also...

Is there a #MSCOVID-19 Surge? How about the Zombie apocalypse? What about pregnancy?

You never know what the media may pick up and this is one that the “doom and gloomer”s may like. The authors suggest that as it has been suggested that MS may be caused by virus Therefore SARS-CoV-2 may cause a surge in MS and as JC virus in the brain is a problem with natalizumab, because SARS-CoV2 causes neurological problems, then you have to be concerned. Although never say...

Meta Analysis #MSCOVID19

Sharifian-Dorche M, Sahraian MA, Fadda G, Osherov M, Sharifian-Dorche A, Karaminia M, Saveriano AW, La Piana R, Antel JP, Giacomini PS. COVID-19 and disease-modifying therapies in patients with demyelinating diseases of the central nervous system: A systematic review. Mult Scler Relat Disord. 2021 Jan 29;50:102800 If you want to see a more recent review of the influence of COVID-19 you can see...

The New England Diet for MS Reduction

MD doesn’t do diets….No it is not that MD doesn’t do diets, it is that ProfG is your Diet Man….I don’t have the interest to research diets and to make suggestions. However, you have been saying I’m fed up with the COVID stuff why not do MS stuff. So is today’s fluffy post is about lifestyle, we can have a look at the mediterranean diet. But I think we...

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