ArchiveMarch 2021

How much dimethyl fumarate gets in the brain

A couple of weeks ago someone asked about the penetration of dimethyl fumarate into the central nervous system. The active breakdown product of DMF is monmethyl fumarate. T Max is the time to the maximal concentration Edwards KR, Kamath A, Button J, Kamath V, Mendoza JP, Zhu B, Plavina T, Woodward C, Penner N. A pharmacokinetic and biomarker study of delayed-release dimethyl fumarate in subjects...

MS Octupus is hatching

The octupus is an incredibly intelligent mollusc and starts life as an egg. If you want to see an amazing film watch “My Octupus Teacher” its on Netflix (See trailer.) set in South Africa. Maybe it will be the last time you will eat one! I have seen the birth of this octupus (see below) It is a massive (90 x 60cm) bronze made in the East End of London by an amazing artist. I first saw...

Mind matters

New research from Brazil suggests that the act of walking when you have MS uses up greater cortical resources than if you don’t have MS; especially in the frontal and parietal cortical areas. Their hypothesis is that this increased activity is a compensatory response for the subcortical damage that occurs with MS. This is a plausible as majority of MS lesions occur in a periventricular...

Can’t Neuros just flipping Read!

This is one of those posts where I bring our profession into disrepute. The neuros are gods when they do something that works and yes I am not worthy when it comes to licking the bosses boots, but eventually you have to crack. I have been reporting year after year as a stocking filler for when ProfG or some other neuros posts something of interest. Therefore I have read a lot and you see this...

Like a Good Wine, MS DMT efficacy takes time

Determinants of therapeutic lag in multiple sclerosis. Roos I et al. Mult Scler 2021 PubMedhttps://doi.org/10.1177/1352458520981300 Article information  A good wine takes time……and you accept this but this is also true for MS disease modifying treatments. ProfG brought the idea of the length dependent axonopathy (Long nerve tracks take on damage more quickly) and therapeutic lag...

#MSCOVID19 MDs Saturday COVID lunch

Wow what a week Vaccinations Work…If your DMT lets them Shah et al. Effect of vaccination on transmission of COVID-19: an observational study in healthcare workers and their households. MedRXiv doi:  A national study determined documented COVID-19 cases and hospitalizations in unvaccinated household members of vaccinated and unvaccinated healthcare workers. The cohort comprised of...

Progressive MS is a T cell Problem?

Kaufmann M, Evans H, Schaupp AL, Engler JB, Kaur G, Willing A, Kursawe N, Schubert C, Attfield KE, Fugger L, Friese MA. Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis. Med (N Y). 2021 Mar 12;2(3):296-312.e8. Multimodal single-cell profiling of blood and spatial RNA sequencing of brain tissueVLA4 blockage mobilizes CD161+/LTB+...

#MSCOVID19 Newsflash. Early data on vaccine responses appears.

Good news for cladribine, not so good for ocrelizumab and fingolimod Data has surfaced today at an International MS meeting on the impact of MS disease modifying treatments and it looks like it is supporting the biology. As presented by Dr Anat Archirion from Israel and as anticipated from past vaccination data, there was a poor (less than 20%) seroconversion (assessed using the Eurimmune Ig...

BartsMS #MSCOVID19 #vaccination advice: The update of the update of the…

So, six weeks ago we said this: BartsMS – The latest “final” update on SARSCoV2 vaccinations in the context of disease modification However, in the COVID19 era, the life cycle of evidence emerging, and us reflecting on it, has shrunk. Hence, another update on our vaccine advice was overdue: COVID-vaccines-DMT_BartsMS-guidance_March-update_final There are two changes to the...

Doing the Hokey Cokey to work out what starts MS:-)

Sing to the Hokey Cokey. (Not sure (click here) it can be you exercise for the day:-). You put the dodgey ideas in, you throw the logic out, in out, in out, you shake it all about, you do the “Frontiers” con job (Appoint editors to get their mates to publish in a Froniers journal at $2-3,000 a time….Ker-ching, Ker-Ching) and flip-flop all around and thats what’s its all...

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