ArchiveMarch 2021

#MSCOVID19 Newsflash. Early data on vaccine responses appears.

Good news for cladribine, not so good for ocrelizumab and fingolimod Data has surfaced today at an International MS meeting on the impact of MS disease modifying treatments and it looks like it is supporting the biology. As presented by Dr Anat Archirion from Israel and as anticipated from past vaccination data, there was a poor (less than 20%) seroconversion (assessed using the Eurimmune Ig...

BartsMS #MSCOVID19 #vaccination advice: The update of the update of the…

So, six weeks ago we said this: BartsMS – The latest “final” update on SARSCoV2 vaccinations in the context of disease modification However, in the COVID19 era, the life cycle of evidence emerging, and us reflecting on it, has shrunk. Hence, another update on our vaccine advice was overdue: COVID-vaccines-DMT_BartsMS-guidance_March-update_final There are two changes to the...

Rehab update: taking back control

Barts-MS rose-tinted-odometer: ★★★★★ After my life-threatening accident last year I returned to work on the 1st of February against the advice of many people. I thought getting back to work would help with my overall rehabilitation. Yes, in the sense that commuting to work and adapting my exercise programme to fit in with my workday would help my recovery. But no in the sense that my energy...

Doing the Hokey Cokey to work out what starts MS:-)

Sing to the Hokey Cokey. (Not sure (click here) it can be you exercise for the day:-). You put the dodgey ideas in, you throw the logic out, in out, in out, you shake it all about, you do the “Frontiers” con job (Appoint editors to get their mates to publish in a Froniers journal at $2-3,000 a time….Ker-ching, Ker-Ching) and flip-flop all around and thats what’s its all...

Will the real MS stand up again

Uher T, Krasensky J, Malpas C, Bergsland N, Dwyer MG, Kubala Havrdova E, Vaneckova M, Horakova D, Zivadinov R, Kalincik T. Evolution of Brain Volume Loss Rates in Early Stages of Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021 Mar 16;8(3):e979. Objective: To describe the dynamics of brain volume loss (BVL) at different stages of relapsing-remitting multiple sclerosis (RRMS), to...

Social media is not media

Facebook, Twitter, Instagram, Tik Tok create an escapist persona for many of us staged by influencers, experts and self help gurus. It is the first thing that we check in the morning and the last thing we glance at before dropping off to sleep. Research has shown that we spend more time on social media sites than actually making true human connections. However, having an illness isolates you like...

Are you ready for the “dørstokkmila”?

One of the things that has struck me during this COVID-19 pandemic is how little many pwMS move. Very often I speak to young pwMS that have low levels of disability but hardly reach 2000 steps a day, which corresponds to 1.5 K or 1 mile. Similarly, also people with advanced MS told me that lockdown has been detrimental to their levels of physical fitness and report an increase in spasms and...

Childhood EBV and contraception

If EBV is the cause of MS then you expect that everybody should be infected with EBV. If people are not infected and get MS the causal link may become tenuous. In this study they look for EBV negative children with MS and find negative people. Does ProfGs idea go down in flames? They find 25/189 cases and so you would say the EBV hypothesis is on dogey ground.. They look harder and now come to...

#MSCOVID19 MDs Saturday Lunch: The first 12 months and further evidence that BartsHealth were right to ignore the JCVI.

You may have heard that ProfG was not happy to have too much COVID news, as it was frightening you off. So I have decided to do MDs Saturday COVID Lunch. However, safe to say I will not be doing this on video to MD2 playing Rock Tunes and me dancing in a top that is a bit too tight for comfort….Don’t understand search Toyah’s (Wilcox) and Roberts (Fripp) Sunday Lockdown...

What next the B cell super fortress…Bad guy

Immunologists love to pigeon hole themselves and their ideas to make it simple like Th1 (Bad CD4 T cells), Th2 (Good CD4 T cells) then came Th17 (even badder CD4 T cells when we could show that Bad CD4 T cells were bad enough) but humans didnt really split that way TH0 and we have had M1 (bad macrophages) and M2 (good macrophages), which are the same cell at differnt stages of development, A1...

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