ArchiveMarch 2021

Will the real MS stand up again

Uher T, Krasensky J, Malpas C, Bergsland N, Dwyer MG, Kubala Havrdova E, Vaneckova M, Horakova D, Zivadinov R, Kalincik T. Evolution of Brain Volume Loss Rates in Early Stages of Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021 Mar 16;8(3):e979. Objective: To describe the dynamics of brain volume loss (BVL) at different stages of relapsing-remitting multiple sclerosis (RRMS), to...

Social media is not media

Facebook, Twitter, Instagram, Tik Tok create an escapist persona for many of us staged by influencers, experts and self help gurus. It is the first thing that we check in the morning and the last thing we glance at before dropping off to sleep. Research has shown that we spend more time on social media sites than actually making true human connections. However, having an illness isolates you like...

Are you ready for the “dørstokkmila”?

One of the things that has struck me during this COVID-19 pandemic is how little many pwMS move. Very often I speak to young pwMS that have low levels of disability but hardly reach 2000 steps a day, which corresponds to 1.5 K or 1 mile. Similarly, also people with advanced MS told me that lockdown has been detrimental to their levels of physical fitness and report an increase in spasms and...

Childhood EBV and contraception

If EBV is the cause of MS then you expect that everybody should be infected with EBV. If people are not infected and get MS the causal link may become tenuous. In this study they look for EBV negative children with MS and find negative people. Does ProfGs idea go down in flames? They find 25/189 cases and so you would say the EBV hypothesis is on dogey ground.. They look harder and now come to...

#MSCOVID19 MDs Saturday Lunch: The first 12 months and further evidence that BartsHealth were right to ignore the JCVI.

You may have heard that ProfG was not happy to have too much COVID news, as it was frightening you off. So I have decided to do MDs Saturday COVID Lunch. However, safe to say I will not be doing this on video to MD2 playing Rock Tunes and me dancing in a top that is a bit too tight for comfort….Don’t understand search Toyah’s (Wilcox) and Roberts (Fripp) Sunday Lockdown...

What next the B cell super fortress…Bad guy

Immunologists love to pigeon hole themselves and their ideas to make it simple like Th1 (Bad CD4 T cells), Th2 (Good CD4 T cells) then came Th17 (even badder CD4 T cells when we could show that Bad CD4 T cells were bad enough) but humans didnt really split that way TH0 and we have had M1 (bad macrophages) and M2 (good macrophages), which are the same cell at differnt stages of development, A1...

Another Eagle has landed

Another Sphingosine -1-phosphate modulator has arrived in the USA, first we had Fingolimod, then Siponimod, the ozanimod and now ponesiod. The later three target S1P1 and S1P5 which one would you choose? There are five main receptors S1P 1 to SP15 and the major immune effects are mediated by S1P1. This is expressed by astrocytes and lymphocytes. The mechanism linked to the action is by stoppoing...

Identifying myelin repair agents. First we need to know if they are drugs.

Fed up with COVID classics, how about some mouse remyelination studies? Being a scientist I know that the mechanism is often more important that the therapeutic aspect and therefore basic scientists often do not think of the practicalities of their discoveries. Many remyelinating agents have been shown to influence the signalling cascades of myelinating cells and whilst they may work wonders in...

Early MRI says cladribine works within a few months…Where should Prof Freedman really look

Freedman MS, Coyle PK, Comi G, L Scarberry S, Damian D, Hyvert Y, Dangond F, Galazka A, Jack D, Lebson LA, Leist TP. Early MRI outcomes in participants with a first clinical demyelinating event at risk of multiple sclerosis in the ORACLE-MS study. Mult Scler J Exp Transl Clin. 2021 Feb 24;7(1):2055217321990852 Background: In the Phase 3, 96-week ORACLE-MS study, cladribine tablets 10 mg (3.5...

Why would you make a comic book about that?

Things neurologists don’t expect to hear during a consultation, example #327: “I’ve made a comic book about having MS, and you appear as a character on the first page! Can I send you a copy?” But that is exactly what I said to Prof K last time we met. And here is that first page: I know he doesn’t really look anything like that. I don’t have an enormous Mohican either. And more importantly, I...

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