ArchiveApril 2021

Should we abandon the ADIOS study?

Barts-MS rose-tinted-odometer: ★★★ If you have been on ocrelizumab for two years would you be prepared to participate in the ADIOS (adaptive dosing ocrelizumab study)? One of the study arms would mean that you would not receive any ocrelizumab until you had a relapse or new MRI activity. In other words, we would be using ocrelizumab like we use alemtuzumab or cladribine, i.e. as an immune...

#MSCOVID19 Astrazeneca Vaccine and Blood Clot information

Here are some links to information about the Astrazeneca vaccine and small risk of blood clotting, which have just gone live. Hopefully these will help with your questions. Press release MHRA issues new advice, concluding a possible link between COVID-19 Vaccine AstraZeneca and extremely rare, unlikely to occur blood clots – GOV.UKThe benefits of vaccination continue to outweigh any risks...

#MSCOVID19: triMSx-online

You may remember that about 6 years ago the idea was germinated on this blog to launch an online version of ECTRIMS to reach people in low- and middle-income countries and to allow more women with family commitments to attend meetings. The other aim was to usher in the next generation of young MSologists; more women, younger people, more ethnic diversity and from all regions of over the world, i...

Apology to people with MS and the Neurologists who were upset and offended by my post

I write to apologise to anybody who was upset or offended by my recent post on AttackMS, which is in support of a trial of natalizumab in people who likely have MS at the time before their diagnosis. Foolishly, I contrasted this with a post on repeated monitoring of people over a thirty-year period, entitled “Same time next year”. This was inappropriate and insensitive and I apologise...

“Only your eyes can show the suffering” dixit Fausto Coppi

Once upon a time, there were cyclists as Fausto Coppi. He was the kind of guy that attacked 5 km after the start of the race (Milan San-Remo 1946), and then dropped the rest of the lead group with 14 minutes on the ‘Passo del Turchino’ or ‘who-wins-on-the-Turchino-wins-the-race’. He not only won the Tour de France twice, he did it with a ‘martian’ dominance. In 1949, there was a 14’ difference...

The second first case of the trickle..drip drip, drip,ocrelizumab and COVID-19 vaccines

In this individual ocrelizumab was used for 2 years. The person was vaccinated about two weeks after last infusion and the second Pfizer dose 3 weeks later. Nearly 3 weeks later they tested positive for COVID-19, so had been infected. A few days later there showed an IgM response but no IgG response. But we are no wiser…were they going to seroconvert to make an IgG response? No time to find...

Will the real slim-shady please stand up?

Vitamin D is one of the biggest confounders in MS clinical trials. It’s like a chess piece, where every move has an effect on the outcome. This latest piece of research from Romania studying the effect of Copaxone (immune modulator) versus prednisone (steroid) on circulating immune complexes (auto-antibodies) in RRMS, shows exactly this. The investigators found low serum levels of immune...

How soon does the shredder begin to shred?

Barts-MS rose-tinted-odometer: zero-★s She was only 26-years and she couldn’t understand why she was falling behind her peers at work. She started working at an ultra-competitive law firm after finishing as one at the top of her peer group at Oxford. She was clearly the best-performing intern in the 2017 intake, which is why she was kept on after her internship. However, things were now...

The Trickle begins..waiting for the Flood! Blunted vaccine responses and CD20-depleting antibodies

The case reports are starting to arrive “We present a patient with MS on ocrelizumab, who received the Pfizer mRNA COVID-19 vaccine, and did not seroconvert 27 days after the second vaccine dose as measured by an FDA approved Anti-SARS-CoV-2 S assay”. He received his first dose of SARS-CoV-2 (Pfizer) vaccine 5 months after ocrelizumab infusion, followed by the second dose...

#MSCOVID19 – AstraZenca Vaccine Update

Barts-MS rose-tinted-odometer: ★★ In response to a comment from one of our readers. We have not directly addressed the thrombosis AstraZeneca vaccine issue as we are not vaccinologists or haematologists. But as there seems to a lot of anxiety around this issue a short blog post about the potential risks may allay your fears. I received the following email, from Professor Marcel Levy (Consultant...

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