Snooze it or Lose it


ProfG has repeatedly said ensure your sleep health is good. I sadly am now on course for a 30% increase risk of dementia….Maybe that,s the problem ;-)..I guess time for some more snoozing and snoring and no more 2 am zooms.

Sabia, S., Fayosse, A., Dumurgier, J. et al. Association of sleep duration in middle and old age with incidence of dementia. Nat Commun 12, 2289 (2021).

Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, we examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up. Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (7 h) sleep duration, although this was imprecisely estimated for sleep duration at age 70 (hazard ratios (HR) 1.22 (95% confidence interval 1.01–1.48), 1.37 (1.10–1.72), and 1.24 (0.98–1.57), respectively). Persistent short sleep duration at age 50, 60, and 70 compared to persistent normal sleep duration was also associated with a 30% increased dementia risk independently of sociodemographic, behavioural, cardiometabolic, and mental health factors. These findings suggest that short sleep duration in midlife is associated with an increased risk of late-onset dementia.

Disclaimer: Please note that the opinions expressed here are those of the author and do not reflect the positions of the Barts and The London School of Medicine and Dentistry nor Barts Health NHS Trust or Queen Mary Univeristy of London.

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  • Stop the early hours Zooms MD and reach for glycine supplement instead.

    ‘In summary, we conclude that exogenous glycine promotes sleep by modulating thermoregulation and circadian rhythms through the activation of NMDA receptors in the SCN. Studies are required to further elucidate the mechanisms by which glycine orchestrates SCN function with the proper timing and magnitude, which will provide a better understanding of the physiological role of glycine and its therapeutic potential for improving sleep quality.’

    Btw it’s SO nice to have you back!

  • Another amino acid, tryptophan helps sleep and mood, it’s used to make serotonin, serotonin help makes melatonin, which is thought to potentially lower relapses and I believe melatonin study’s are ongoing to see if it can have an effect on relapse rates in MS.

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