AAN2021 T cell response in COVID-19 infected people treated with CD20 antibodies.

A

As profG has made the post here is the data

First up we have Asplund Högelin, Klara and Ruffin, Nicolas and Pin, Elisa and Månberg, Anna and Hober, Sophia and Gafvelin, Guro and Grönlund, Hans and Nilsson, Peter and Khademi, Mohsen and Olsson, Tomas and Piehl, Fredrik and Al Nimer, Faiez, Development of Humoral and Cellular Immunological Memory Against SARS-CoV-2 Despite B-Cell Depleting Treatment in Multiple Sclerosis. SSRN: http://dx.doi.org/10.2139/ssrn.3796531

Korgsgaard et al AAN P15.01 Preliminary results of ongoing prospective study of antibody and T cell responses to SARS-Cov-2 in patients with MD on ocrelizumab or other disease modifying therapies

Assays upto 9 months after infection

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Antibody Assay Ocrelizumab Non-Ocrelizumab

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Elecsys (Spike) 58% (n=19 97% (n=36) p=0.0004

Bead Assay multiple 89% (n=18) 97% (n=34) P=0.27

Neutralizing Antibody (Spike) 62% (n=16) 83% (n=19) P=0.74

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T CELL ASSAY

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ELISPOT (gamma interferon) 80% (n=10) 82% (n=17)

TruCulture interferon & IL-12 39% (n=17) 39% (n=26)

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So there is a T cell response in people treated with ocreliziumab. This is good news but this group will not be typical of the general population, who show no or mild symptoms as it is clear that for many people infected with COVID-19 the antibodies don’t hang around for ever.

Disclaimer: Please note that the opinions expressed here are those of the author and do not reflect the positions of the Barts and The London School of Medicine and Dentistry nor Barts Health NHS Trust or Queen Mary Univeristy of London.

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