The case reports are starting to arrive
“We present a patient with MS on ocrelizumab, who received the Pfizer mRNA COVID-19 vaccine, and did not seroconvert 27 days after the second vaccine dose as measured by an FDA approved Anti-SARS-CoV-2 S assay”.
He received his first dose of SARS-CoV-2 (Pfizer) vaccine 5 months after ocrelizumab infusion, followed by the second dose 21 days later. There was a moderate post-vaccination systemic reaction with myalgias and fatigue. The person received another ocrelizumab infusion 9 days after the second dose of the vaccine. This is because in other studies it has been shown that maximal antibody responses can be detected within 7 days of the second vaccination. At the time of infusion he tested negative for antibodies to the SARS-CoV-2 nucleoplasmid antigen so had no seemingly been naturally infected.
So this is ominus as the vaccination was used at times to give the best opportunity to give a response within a six monthly dosing cycle and there was none. So now the question is can we find a condition that allows seroconversion because the writing is on the wall given the information that has come out of Israel and so most people will not seroconvert. So next question is will be , is there a T cell response? Likewise if your CD19 B cells start to recover can you make an antibody response. About 5 % of people have recovered their cells before 6 months or will you need to wait a little bit to convert. Most people in UK will have been offered their jab before we get sufficient insight, but there are other parts of the World yet to get a vaccine and importantly there may be boosters to deal with.