ArchiveMay 2021

Thank You, Your COVID Vaccine experiences

Experience with the COVID-19 AstraZeneca vaccination in people with multiple sclerosis.Allen-Philbey K, Stennett A, Begum T, Johnson AC, Dobson R, Giovannoni G, Gnanapavan S, Marta M, Smets I, Turner BP, Baker D, Mathews J, Schmierer K.Mult Scler Relat Disord. 2021 May 18;52:103028. doi: 10.1016/j.msard.2021.103028. Online ahead of print. Background: Some people with multiple sclerosis...

Saturday COVID Lunch

T cells responses in B cell response immunocompromised people This is not MS but I think it is telling us what is going to happen as I am seeing this over and over again. We can predict that people on CD20-depleting antibodies are going to make a poor anybody response, but a greater proportion of people will make a T cell response against the virus. It think the question is how many?. At present...

Bladder care is self-care!

Over the past year, I became surprised how many pwMS consider their overactive or neurogenic bladder symptoms as ‘normal’, ‘part of the disease’ or ‘something you have to learn to live with’. I spent many hours explaining pwMS that this is not the case, that these symptoms are, at least partially, treatable, and that treating these symptoms is often more impactful on pwMS’s quality of life in the...

The Fourth eagle has landed

First we had fingolimod, then came siponimod, then oxazinimod and now we have ponesimod after the EMA approved it. These are all Sphingosine-1-phosphateone receptor modulators. Ponvory (ponesimod) is approved for the treatment of adult patients with relapsing multiple sclerosis (RMS) with active disease defined by clinical or imaging features. “Relapsing multiple sclerosis is an unpredictable and...

The causative link of EBV and MS explained?…ProfG will be happy

ProfG has been on an EBV crusade, but why or how does it cause/trigger MS? HLA-DRB1*15:01 is a coreceptor for Epstein-Barr virus, linking genetic and environmental risk factors for multiple sclerosis. Eur J Immunol 2021. The strongest genetic and environmental risk factors for multiple sclerosis (MS), an inflammatory central nervous system disease, are HLA-DRB1*15:01 and Epstein-Barr virus (EBV)...

Artificial intelligence knocking on the wall!

Applications of artificial intelligence (AI) are becoming more and more common in daily life, and medicine. It’s public knowledge that AI algorithms are much better at detecting a pneumonia on a chest X-ray than radiologists of flesh, blood and … insomnia. A similar problem arises when judging whether MS lesions on a brain scan have increased in volume over time. (Un)fortunately, lesions never...

ChariotMS – we’re rolling !

And we’re off… Almost exactly three years after submitting our outline application to the NIHR-EME, the first site initiation visit of ChariotMS will take place TODAY at my home site, The Royal London Hospital. We are expecting the first of 200 people with advanced MS to enrol in June. And as the remainder of 20 sites across all nations of the UK will open over the next three months...

Not so much of a cure then? Anti-CD20s fall short of the finish line.

Drum roll please!…. It was only a matter of time before someone designed this experiment. Albeit, it’s in an animal model, but the content is still by far the juiciest I’ve seen in MS research this year. The major finding of this work is that depleting B cells alone using anti-CD20s doesn’t get rid of all inflammation in the neuronal tissue. The authors of this work...

Blog Essay: Mouse EAE is a T -cell disease….Discuss

It is exam times at university and if I was setting an exam for the London School of EAEers, this is the title I would give. OK it is supposed to be contentious. Maybe it is time to retire as that Mr Hyde keeps popping up As a card carrying EAEer I think I can comment on this one presented by NDG today and hope that it my constructive comments will get me into trouble with the EAE trade Union...

Tumour-like lesions 2 days after drinking fizzy pop.

I have to give a disclaimer that I have just made this up!…….No, I didn’t work for the BCC:-), but it could be a possibility that after drinking: Lip-smacking, ace-tasting, motivting, good, buzzing-cool, walking-high, living, evergiving, cool fizzing……pop…….yep I don’t want to say anything specific, in case I get sued for linking anything to...

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