HLA-DRB1*15:01 is a coreceptor for Epstein-Barr virus, linking genetic and environmental risk factors for multiple sclerosis. Eur J Immunol 2021.
The strongest genetic and environmental risk factors for multiple sclerosis (MS), an inflammatory central nervous system disease, are HLA-DRB1*15:01 and Epstein-Barr virus (EBV). They say
“The mechanisms through which EBV exerts its role in MS are currently unknown”…Are they?
“While it is therefore well known that HLA class II molecules serve as coreceptors for EBV, it was hitherto unknown whether this extends to HLA-DRB1*15:01″…..Is it?
However what does the paper show?.
Should have gone to Spec Savers to get some reading glasses?
However by taking an a B cell line with CD21 that did not express HLA-DR and couldn’t be infected with EBV, they added HLA-DRB1*15.01 and the B cells got infected so they is the genetic link
“This work provides proof of principle that HLA-DRB1*15:01 acts as a coreceptor for EBV on a B cell line. It also evokes the intriguing hypothesis that one mechanism underlying the association of HLA-DRB1*15:01 and MS could be the function of HLA-DRB1*15:01 as a coreceptor for EBV”.
So this study confrims what others have suggested. But how does EV infecting B cells create MS, you can read a hypothesis in one of our papers
Learning from other autoimmunities to understand targeting of B cells to control multiple sclerosis.Baker D, Pryce G, Amor S, Giovannoni G, Schmierer K.Brain. 2018; 141:2834
Anyway another piece in the Jigsaw
CoI I have nothing to do with Spec Savers
Disclaimer: Please note that the opinions expressed here are those of author and do not necessarily reflect the position of the Barts and The London School of Medicine and Dentistry nor Barts Health NHS Trust.