ArchiveJune 2021

How does fingolimod work?

We have been told that fingolimod inhibits the migration of T cells out of lymph nodes as a working mechanism, but I would also argue that it inhibits B cells migration but that is not all. it also inhibits macrophage function. So if we believe that there are bad macrophages it should be beneficial. Sferruzza G, Clarelli F, Mascia E, Ferrè L, Ottoboni L, Sorosina M, Santoro S, Moiola L...

Infection risk secondary neutropenia with ocrelizumab

All drugs have a range of predictable side effects. In the case of immunosuppressants/immune depleting agents this is a low white cell count, which increases the risk of infection in the short- or long-term. Ocrelizumab is a monoclonal anti-B-cell (anti-CD20) treatment that specifically targets B-cells, but it may also have what we in the business call off target effects on other immune cells...

Drip, Drip Drip, COVID-19 vaccination results….France begins to support Israeli Conclusions

 Share Impact of disease-modifying treatments on humoral response after COVID-19 vaccination: A mirror of the response after SARS-CoV-2 infection.Bigaut K, Kremer L, Fleury M, Lanotte L, Collongues N, de Seze J.Rev Neurol (Paris). 2021 Jun 16:S0035-3787(21)00569-5.  Objective: To analyze the humoral response after COVID-19 vaccination in patients with multiple sclerosis (MS) according to disease...

Memory B cells for MS….It’s nowt to do with me

This is a review that is open access for you to read.. I feel abit airbrushed but hey DiSano KD, Gilli F, Pachner AR. Memory B Cells in Multiple Sclerosis: Emerging Players in Disease Pathogenesis. Front Immunol. 2021 Jun 8;12:676686. doi: 10.3389/fimmu.2021.676686. Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Once thought to be primarily driven...

Watch Out Ted…Can you get Doggy MS?

In case you don’t know Ted is the name of a cute pootch from one of the readers. Like many people they got a Dog during lock down. But could Ted become the solution to MS? This week I did a post about the name Mouse Doctor and if you remember, we made a comment that people working on cats/dogs and monkeys get special attention when it comes to generating the ire of the anti-vivs...

MD Merch

After my post you have asked about the Merch. Although they are all drawn by me, to avoid any copyright claims, e.g. the original felt model was made by the House of Mouse, the merch is used as a gift, so they are limited edition and often bespoke. Believe it or not the T shirt shop that houses all my designs have updated their software due to the down fall of “Flash” and has...

#MSCOVID19…The CD20 problem

So what do I know or what do I think I know. We have seen a fair amount of data in cancer, arthritis and even abit in MS (a) Ocrelizumab-induces longer-lasting B cell depletion than rituximab. (b) Ocrelizumab and rituximab both inhibit active MS (c) Antibody responses to novel antigens are blunted by anti-CD20 treatment and this will include response to COVID (d) Antibody responses are blunted...

Are you a Gunner’s supporter?

If you have MS and want to #GetVaccinatedASAP and have yet to be allocated a booking for a vaccine you can have the first dose of the Pfizer-BionTech mRNA COVID-19 vaccine and have a tour of the Emirate’s stadium, which is home to, arguably the most famous London football club Arsenal FC, also known as the Gunners. Click here to sign-up, places are limited.


Congratulations to Professor Alan Thompson

The MS-Blog would like to congratulate Professor Alan Thompson on receiving the MSIF’s 2021 Charcot Award. Professor Alan Thompson is Dean of the Faculty of Brain Sciences at UCL in the UK and a well-known MS researcher. The Charcot Award recognises a lifetime of achievement in outstanding research into understanding and treating MS. Congratulations!

Why the name…MD?

This weekend I did a joke that fell abit flat….I suggested that Aaron Booster…..the Amish/Pilgrim Neuro:-) OK maybe not….but look at the the beard and sideburns.(Just realised it is just a beard but different hair colour on the chin)…:-), had joined the fold as ProfK had tweeted about Aaron Boster MD…You may think it is Medical Doctor. But I suggested it said it was...



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