ArchiveJuly 2021

The deluge appearing #MSCOVID19 More evidence for CD8 T cell response in people treated with anti-CD20

Drip Drip Drip its coming as the rain arrives so are those B cell papers I recently saw a colleague who was concerned about whether it was OK to cite a pre-print because it was not peer-reviewed….However this is the new norm and in reality you can review it yourself. Also some reviewed papers are not without issues. You have to determine whether you want to live under a “knowledge...

Home care..Natalizumab style

During the pandemic, avoiding hospitals has been advantageous. Natalizumab is usualy infused in hospital. In this study they looked at infusing at home and they concluded it was safe and cheaper to infuse at home. However, I would start to ask why bother? Subcutaneous natalizumab has been approved and whilst this will be intially administered in the hosptial environment…I can easily see...

Die Wende: Extending the anti-CD20 overdose

It’s a bittersweet fact that wars spark big leaps in science, and this has unfortunately also been true for our fight against the COVID-19 pandemic. When it comes to treating MS, susceptibility to common infections and ability to mount vaccine responses have become important themes among neurologists. Furthermore, pwMS prefer drugs that do not require regular hospital or phlebotomist visits. One...

Antibodies don’t hang around for ever, lets hope the COVID-19 virus doesn’t either

Whilst we are on about antibody responses, this is a study from UK where people got pfizer or astrazeneca vaccine at about 10-11 week intervals and it was evident that antibody levels dropped overtime, so after “Frazer day” (OK abit amateur dramtics) on monday when we were all let loose to spread virus at will. Frazer from Dads Army Remember that the level of protection could drop a...

Road to Impact, By Delaying B cell treatment

In our science jobs we have to justify our use and assess what impact our work has on Society. For Prof G is is easy. He is lead on a clinical trial of drug X and it works and is licensed and so it has impact on people with MS, but maybe drug X gets used in other autoimmunities and the impact gets bigger and it works in Cancer too a bit impact etc. Then there is impact on Society. Manufacturer of...

MS and other neurological disorders in India

This freely accessible article published in Lancet Global Health is the most comprehensive data on the prevalence of neurological disorders across India to date. Around 18% of the worlds population live in India and like other nations they also have a significant level of morbidity related to those with neurological disorders. But, owing to a lack of resources as well as cultural taboos, it has...

ProfK for Number 10

No this is not a call for ProfK to become the next Prime Minister,but I am sure he would have done a better job. However, as German with a knowledge of oral Cladribine what are his Expert Thoughts? You will note there are nine german neurologists….PofK can be the tenth one Stangel M, Becker V, Elias-Hamp B, Havla J, Grothe C, Pul R, Rau D, Richter S, Schmidt S. Oral pulsed therapy of...

Advice from Van the Man Van-Tam

So to keep you in the loop, my spies have intercepted a communication by Prof Van-Tam, OK…it was sent to the Doctors. COVID-19 causes a variety of symptoms, Dr Angry says symptoms of COVID include loss of taste and you can see this symptom is on the increase all around London. Get ready for a Booster in Autumn 2021 Anyway back to the Medical Van th Man..He wrote: As you will be aware...

CD20 and COVID-19

The CD20 onslaught continues at a pace and there is no refuting it, anti-CD20 depletion blocks the formation of vaccine response. I have seen this occur irrespective of the vaccine that was used. I am sorry to say if you are on anti-CD20 you are going to see this over and over again…it will be like-water torture, drip, drip, drip. Yep and I control the tap (faucet for our American readers:...

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