COVID lunch

C

Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccinationDavis, C., Logan, N., Tyson, G., Orton, R., Harvey, W., Haughney, J., Perkins, J., The COVID-19 Genomics UK (COG-UK) Consortium, , Peacock, T., Barclay, W. S., Cherepanov, P., Palmarini, M., Murcia, P. R., Patel, A. H., Robertson, D. L., Thomson, E. C., Willett, B. J.10.1101/2021.06.23.21259327 — Posted: 2021-06-28

Vaccines are proving to be highly effective in controlling hospitalisation and deaths associated with SARS-CoV-2 infection but the emergence of viral variants with novel antigenic profiles threatens to diminish their efficacy. Neutralising antibody titres elicited by vaccination with two doses of BNT162b2 were significantly higher than those elicited by vaccination with two doses of ChAdOx1. Fold decreases in the magnitude of neutralisation titre following two doses of BNT162b2, conferred reductions in titre of 7.77, 11.30 and 9.56-fold respectively to B.1.617.1, B.1.617.2 and B.1.351 pseudoviruses, the reduction in neutralisation of the delta variant B.1.617.2 surpassing that of B.1.1351. Fold changes in those vaccinated with two doses of ChAdOx1 were 0.69, 4.01 and 1.48 respectively.

Mix and Match

Strong immunogenicity of heterologous prime-boost immunizations with the experimental vaccine GRAd-COV2 and BNT162b2 or ChAdOx1-nCOV19Agrati, C., Capone, S., Castilletti, C., Cimini, E., Matusali, G., Meschi, S., Tartaglia, E., Camerini, R., Lanini, S., Milleri, S., Colloca, S., Vitelli, A., Folgori, A.10.1101/2021.06.22.21258961 — Posted: 2021-06-28

Here we report on the humoral and cellular immune response in eight volunteers who autonomously chose to adhere to the Italian national COVID-19 vaccination campaign more than 3 months after receiving a single administration GRAd-COV2 vaccine candidate in the context of the phase 1 clinical trial. We observed a clear boost of both binding/neutralizing antibodies as well as T cell responses upon receipt of the heterologous BNT162b2 or ChAdOx1-nCOV19 vaccines. These results, despite the limitation of the small sample size, support the concept that a single-dose of an adenoviral vaccine may represent an ideal tool to effectively prime a balanced immune response, which can be boosted to high levels by a single dose of a different vaccine platform.

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MouseDoctor

3 comments

  • Question really
    I hope relevant but first some history
    MS diagnosed 2005
    Aubaggio started 2016
    Relapse early 2019
    Cladribine y1w1 nov 2019 etc
    y2w1 Cladribine started April 2021 (delay cos of covid Second wave and lymphocytes slow at coming up)
    Had COVID Pfizer jab jan and feb 2021

    So here’s question- need blood test at end of month anyway – is it possible to get my covid antibodies checked at same time?
    I can get a private test but will that just indicate y/n ? I’m keen to know if cladribine may have knocked my covid antibodies that were created following jab? If a big knock I’ll be super careful until I get my booster – if the clad has not affected them I’ll just be careful!

    Will it be rude to ask blood people to check – happy to go private ?
    Or am I just worrying too much – or will it not make much difference and the test won’t give me a specific pointer anyway?
    Are there similar words of wisdom available for other pwms who majority are between first jabs and booster ie if they want to check antibody levels – if that is actually a thing – may assist especially as rates accelerating atm in UK?
    Hope that makes sense!

    • 1) Blood test…time? Yes. You are now 5 months on levels could drop
      2) Private test..I dont know it depends whats offered a Yes/No is unsatisfying…You are likely to be positive being dosed a 13 months after dose
      What does the test measure…anti-spike anti-receptor binding domain.
      3) If you dont ask you wont get
      4) Worrying too much…Probably yes you will have made a response
      5) Some of the tests are not quantitative
      6) Levels between first and second jab are low and jump up after second jab……they will go up after booter

      • That’s great – so the fact I had y2 w1 and w2 cladribine in April and May this year following on from my covid jabs in January and February is not going to necessarily affect the antibody response following vaccination I have created etc – that’s the crux
        And no simple way of finding out anyway so just hang on to October to get by booster (and winter fly!) jabs
        That makes sense -thx v much

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