Good news for fingolimod vaccine failures perhaps?

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The problem child for covid-19 vaccine responses is fingolimod maybe the solution is to have another vaccine dose with RNA vaccine as people with transplante responded after three vaccine cycle

Comparison of infected and vaccinated transplant recipients highlights the role of Tfh and neutralizing IgG in COVID-19 protectionCharmetant, X., ESPI, M., Benotmane, I., Heibel, F., Buron, F., Gautier-Vargas, G., Delafosse, M., Perrin, P., Koenig, A., Cognard, N., Levi, C., Gallais, F., Maniere, L., Rossolillo, P., Soulier, E., Pierre, F., Ovize, A., Morelon, E., Defrance, T., Fafi-Kremer, S., Caillard, S., Thaunat, O.10.1101/2021.07.22.21260852 — Posted: 2021-07-24

Transplant recipients, which receive therapeutic immunosuppression to prevent graft rejection, are characterized by high COVID-19-related mortality and defective response to vaccines. Having observed that previous infection by SARS-CoV-2 but not the standard “2 doses” scheme of vaccination, provided complete protection against COVID-19 to transplant recipients, we undertook this translational study to compare the cellular and humoral immune responses of these 2 groups of patients. Neutralizing anti-Receptor Binding Domain (RBD) IgG were identified as the critical immune effectors associated with protection. Generation of anti-RBD IgG was dependent upon spike-specific T follicular helper (Tfh) CD4+ T cells, which acted as limiting checkpoint. Tfh generation was impeded by high dose mycophenolate mofetil in non-responders to vaccine but not in infected patients, suggesting that increasing immunogenicity of vaccine could improve response rate to mRNA vaccine. This theory was validated in two independent prospective cohorts, in which administration of a 3rd dose of vaccine resulted in the generation of anti-RBD IgG in half of non-responders to 2 doses.

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MouseDoctor

4 comments

  • Good news! Just got third vaccination here in France as blood test showed zero antibodies after two Pfizer shots. So third time lucky!

      • Will do. I am being treated in Basel Switzerland and they seemed unaware that there was a problem with fingolimod, but I live just over the border in France and the French are aware of the problem and were pleased to give a third jab.

        • They must like under a rock in CH the achiron data was published months ago…maybe they are in denial

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