MSCOVID-19 Vaccinated people can get infected.

M

I guess you know this already but here is some info from arthritis. You can get COVID-19 if you have been vaccinated but hopefully it will limit the severity of the disease. Therefore remain cautious and sensible

Clinical characteristics and outcomes of COVID-19 breakthrough infections among vaccinated patients with systemic autoimmune rheumatic diseasesCook, C., Patel, N., D’Silva, K., Hsu, T. T.-Y., DiIorio, M., Prisco, L., Martin, L., Vanni, K. M. M., Zaccardelli, A., Todd, D. J., Sparks, J., Wallace, Z.10.1101/2021.08.04.21261618 — Posted: 2021-08-05

Objective To describe the characteristics of COVID-19 vaccine breakthrough infections among systemic autoimmune rheumatic disease (SARD) patients. (So this is not MS).

Methods We identified SARDs patients in a large healthcare system with COVID-19 vaccination at least 14 days prior to a positive SARS-CoV-2 molecular test. Details of the SARD diagnosis, vaccination status, and COVID-19 infection were extracted.

Results Of 340 confirmed COVID-19 infections among SARDs patients between December 11th, 2020 (date of first COVID-19 vaccine approval in the US) and July 30th, 2021, we identified 16 breakthrough infections. Seven (44%) received the Pfizer-BioNtech vaccine, five (31%) received the Moderna vaccine, and four (25%) received the Janssen/Johnson & Johnson vaccine. The most common SARDs included rheumatoid arthritis (6, 38%), inflammatory myopathy (3, 19%), and systemic lupus erythematosus (3, 19%). Rituximab (5, 31%), glucocorticoids (4, 25%), and mycophenolate mofetil (4, 25%) were the most frequent treatments. Among the breakthrough infections, 15 (93%) were symptomatic, six (38%) were hospitalized, one (6%) required mechanical ventilation, and two (13%) died. Conclusions Symptomatic, including severe, breakthrough infections were observed in SARDs patients; many were on treatments associated with attenuated antibody responses to vaccination. Further studies are needed to determine the rate of breakthrough infection associated with SARD treatments and other features

Disclaimer: Please note that the opinions expressed here are those of the author and do not reflect the positions of the Barts and The London School of Medicine and Dentistry nor Barts Health NHS Trust or Queen Mary Univeristy of London.

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MouseDoctor

9 comments

  • Feels like every other person in my age group (30s) at the moment in London is catching covid. Friends who’ve been fully vaccinated or 1 vaccine have caught / been rather ill from it. In the news it’s all about less people getting covid but right now I feel like it’s everywhere!!

    • Thats what happens when you have a free for all…Now what was it called Freedom day…maybe the silent purge;-)

  • I have been double vaccinated, but still wary. I just had supermarket delivery, delivery man was wearing mask, waiting outside front door while I unpacked crates. All well and good. But, smelling his aftershave, I thought that if he is carrying delta variant Covid, I’m probably breathing that in too. Oh well. The tomatoes look very nice.

    • You can’t be serious….he is wearing a mask and you’ve been vaccinated. Do we all want to live in a bubble for the rest of our lives?

    • ANONYMOUS 11:34am…….I am with you, can’t be too careful these days!

      ANONYMOUS 8:09pm……Does it really bother you that I still want to ware a mask even though I am vaccinated!?!? And yes, if people do not start respecting this virus, our only chance for survival is probably going to be living in a bubble, unfortunately.

      This is the most deadly pandemic humans have ever been known to experience, so maybe we should be:
      – practicing a bit more caution;
      – respecting each individuals approach to finding control/comfort; and,
      – showing a bit more compassion for the stress this situation continues to put on our healthcare system and the dedicated workers caring for the sick, most of which now are unvaccinated and/or were unlikely to have been regularly warning a mask.

      • Re: most deadly pandemic

        Not true. Bubonic plague, TB, malaria, HIV, cholera and typhus come to mind as being more deadly. Human memory is a strange thing.

          • Anti-vaxxers are perpetuating the pandemic. Just think if we had a vaccine in the 90s for HIV yet the population would refuse the shot. I’m not down playing the pandemic before the vaccine yet a large percentage refuse to accept its urgency.

  • Not meaning to alarm anyone, but this part is relevant:

    “However, our observation that rituximab was the most commonly used DMARD among patients with breakthrough infections and the DMARD used in both fatal cases, raises concerns regarding the ability to mount a T cell immune response against SARS-CoV-2 after B cell depletion. However, both patients also had severe pre-existing interstitial lung disease which likely also contributed to their poor clinical outcome.”

    So risk on anti cd20 is higher but at least terminal outcomes only happened in patients with severe preexisting illness aside of RA.

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