Here we Go Again:-)..CCSVI mark II?


Bateman GA, Lechner-Scott J, Carey MF, Bateman AR, Lea RA. Does the venous pressure theory of multiple sclerosis pathophysiology deserve a second chance? Mult Scler Relat Disord. 2021 Sep 13;56:103262. doi: 10.1016/j.msard.2021.103262.

The theory that multiple sclerosis is related to venous pressure has been discredited due to previous operator dependent diagnostic criteria and premature attempts at treatment. (1) An elevation in venous pressure may only be a component of the compliance changes found in MS. (2) The neck veins may only supply a component of the venous pressure elevation found intracranially. Although a more targeted approach towards neck angioplasty (both towards disease subtype and those with more favorable stenoses) may be beneficial, we would advocate caution. We encourage others to give the venous pressure theory a second chance and to replicate our work.

Where is Nancy Reagan when you want her to say something…Just say…..

Replicate this stuff before Canada throws another few million:-)

About the author



  • It’s ridiculous on the face of it, just like CCSVI. If “venous pressure” is causing MS then treatments like ocrelizumab should do absolutely nothing, unless they are arguing that the venous pressure somehow activates immune cells to do damage, in which case wouldn’t you expect to see people who develop cardiovascular problems simultaneously developing MS-like pathology at a high rate?

    • So you hvae the MS theory Inside out and outside in. The first they think is not autoimmune. They have seen on autopsy that the Myeling is distryed from within. And the many that do not respond on autoimmune therapies? as even HSCT, what kind of disease do they have? not the autoimmune one I guess….

  • Ccsvi, a bunch of snake oil. But what do we know about why lesions can often be found along the deep medullary veins/ perivascular with main axis perpendicular to the lateral ventricles? Why does this signal MS disease vs another ailment?

By MouseDoctor



Recent Posts

Recent Comments