After taking ocrelizumab it seems that many people make a T cell response but do not make much of an antibody response. The emerging data suggest that this is related to B cell levels. On the left you have antibody levles and along the bottom you have B cell levels. The more antibody you make the higher it is on the graph
This is seen in a number of papers
We asked if you take ocrelizumab how long does it take to receach different levels of B cell numbers as this may give you some idea of the chances of making a COVID-19 related antibody response following vaccination.
We have been allowed access to the phase II ocrelizumab study where people had three or four rounds of ocrelizumab and treatment was stopped for 18 months at the end of the study. Remember the antibody hangs around for 5-6 months so this is why you get dosed ever six months. At 0 months (below) people had been on active treatment for 2 or 3 cycles. This is what we found. It is hot off the press never been seen before. We will give the link to the full paper when it appears on MedRXiv. Rememebr some people make antibodies when there are no B cells in the blood
This information is based on research using data from Roche that has been made available through Vivli, Inc. Vivli have not contributed to or approved, and are not in any way responsible for, the contents of this publication. Data analysis, interpretation and conclusions made are independent from Roche.
Disclaimer: Please note that the opinions expressed here are those of the author and do not reflect the positions of the Barts and The London School of Medicine and Dentistry nor Barts Health NHS Trust or Queen Mary Univeristy of London.