The rule number one of fight club is dont talk about fight club!…..Rule number one of pharma club is don’t SH1 on your own product!…..OK to paraphrase….Do not highlight any issues, but there is one Big Issue I want to know about and it has nothing to do with being homeless.
Sales for anti-CD20 have been doing fantastically well and it was all rosey and everyone loved it, but now there is competition and importantly, now there is COVID-19. So with success comes information. This means if something is not quite right, then there are enough cases for it to come to light.
Therefore, of all the MS-DMT (drugs), there is one class of agents where some mud has stuck.
This has been the anti-CD20 antibodies…there has been case report after case report of COVID-19 worsening and as for vaccination there is an endless sea for reports showing that CD20-depletion inhibits vaccine-related antibody responses.
You can make it look not that bad by assaying anti-whole Spike antibodies, which runs around a 40-60% seroconversion or you can assay the receptor binding domain of Spike (s a marker of what blocks infection) with 20-40% seroconversion. You can wonder does this stop the COVID-19 vaccine from working properly and still create a problem if you catch COVID-19?
The UK government has done their upmost to help ensure that the delta variant spreads as much as possible. So we have all enjoyed our hols (AKA COVID spreading events) in Devon and Cornwall, North Wales, Blackpool, Lake district , The High Lands and West Coast of Scotland and the Pembrookshire coast. Maybe Glasgow brought it back from the Euros in London and took it on their hols to the West Coast and Ireland or maybe the Northern Irish have been enjoying the Craic. They have us all carefree with the “let’s get back to normal” attitude as the hospitals slowly fill up with the anti-VAXers and the youth. However, there are a fair number of double Jabbees, showing us that the vaccine efficacy wanes with time and therefore you don’t want to start with a disadvantage.
It says also be careful especially, if you have COVID-19 risk factors
Anti-CD20 gives you that disadvantage and blocks the anti-Vaccine response and even if you do make a response it is lower than if you did not have it. To their credit the manufacturers of the main anti-CD20 have been transparent about what they are going, so the mud throwing rests there, but there is one issue where information has been scant and the manufacturers have been notably quiet…so
Come on Novartis (Fingolimod, Siponimod), Celgene (Ozanimod) and Janssen (Ponesimod)! What is happening with your imods and COVID-19 vaccinations. We want to know!..Is this rule one of Pharma Club?
The agent that has most effectively inhibited the COVID vaccine antibody response is Fingolimod….yet it hardly gets a mention. What is happening? Is this a problem of RNA vaccines or do all vaccines not work very well?
There has been enough time for vaccine studies to occur. Is it that no one takes the imods, so there is not data?
However, the imods are only used in MS and so the faster info on anti=-CD20 occurrs because it is widely used in many different conditions. What happens to the T cell response?/ Come on Companies you must know….it’s a safety thing!
Come on! Do a guest post….the truth will be out sooner or later. Get it out now, so we know what to do with boosters etc. The US has recognised that mycophenylate is a problem and are doing a study on it but as the S1P1 modulators (imods) are MS they have been ignored.
To the science community we know anti-CD20 is the problem kid we have loads of papers, the novelty is in the imods, give us a paper with more than 10-20 cases!
Disclaimer: Please note that the opinions expressed here are those of the author and do not reflect the positions of the Barts and The London School of Medicine and Dentistry nor Barts Health NHS Trust or Queen Mary Univeristy of London.