As you may know I am a big fan of Dr Seheult and Medcram. They are respiratory docs and did a fantastic job in educating me about SARS-COV-2. They also wrote a nice letter to me when I acknowledged them in one of our COVID-19 reviews. This is education and here they ask which vaccine would you have if you can choose a COVID booster.
In US the Vaccine choice is Moderna, Pfizer or JnJ sometime called Jannsen. In UK you get these and the Astrazeneca. Here they ask what would you do if offered a choice?
If you have been reading the blog it is a no brainer if you accept that antibody levels are what is going to prevent you getting infected.
So JnJ induced responses is alot lower than Moderna and Pfizer. If you want to know where AZ stands it is similar to JnJ and so not great. Likewise some of the inactivated vaccine induces an even weaker response.
So this is why in UK the AZ has been binned as a booster. So as we see re-infections in vaccinated individuals it is more likely that this will occur in AZ-vaccinated individuals. This is because the AZ induces much a lower antibody levels and as they wane then the protection goes quicker. I have seen it in some of our samples of how weak the AZ response is. So if you have had AZ and are immunosuppressed you really should get that booster/third dose.
Many of people at BartsMS will have has the AZ vaccine that was given at the EXCEL centre
If you want to watch about Mix and matching vaccines you can but the data in this video https://youtu.be/HSyAssfva8U
If you were on an adenoviral dose and then get RNA dose it is as ggod as two RNA vaccine and was better than wo doses of adenoviral vector