ArchiveNovember 2021

Mission control-Do we have a problem? Anti-neurofilaments antibodies

A lot of faith has been put into measuring neurofilaments, which are structural proteins of nerves as a marker of nerve damage. The idea is that as the nerve gets damaged it releases its contents and you have a marker for progression. However, the reality is that neurofilament light measurent perhaps is a better marker of inflammation induced damage. This floats around the cerebrospinal fluid and...

BK channels a target to save oligodendrocytes?

Maddalena Rupnik, David Baker, David L Selwood Oligodendrocytes, BK channels and the preservation of myelin Oligodendrocytes wrap multiple lamellae of their membrane, myelin, around axons of the central nervous system (CNS), to improve impulse conduction. Myelin synthesis is specialised and dynamic, responsive to local neuronal excitation...

DMT tool vs. The Flawed Milky Way

Urbanisation is by and large a good thing, and I wouldn’t want to miss the buzzing environment of people, culture and, last but not least, cuisine for a second. However, it comes with an annoying side effect: more dangerous city streets. Last week, I had to experience this the hard way. Decennia of intelligent road design couldn’t protect me from being hit by a car while going out for a run. How...

Looks like Prophylactic SARS-CoV-2 antibodies work…Protection against COVID-19 for the immunosuppressed?

This would need to be approved first ProfAngry said many months ago that perhaps the best use of an anti-SAR-COV-2 antibodies was to prevent COVID-19 is people at risk to COVID-19. This would especially be the case for someone that has made no anti-vaccine response like fingolimod or ocrelizumab. However the licenced dose is 600mg and not 1200mg (see below) but things are changing with options...

Ofatumumab and PROMS

I understand oftatumumab is available from BartsHealth. You may have heard of the results from the ofatumumab phase III trial against teriflunomide. Here is some more information compared to placebo for 6 months Kira JI, Nakahara J, Sazonov DV, Kurosawa T, Tsumiyama I, Willi R, Zalesak M, Pingili R, Häring DA, Ramanathan K, Kieseier BC, Merschhemke M, Su W, Saida T. Effect of ofatumumab versus...

The Third Dose verses the Booster

This was addressed in ProfGs MS selfie I think The Booster This issue is causing people problems. For people not on disease modifying drugs and therefore likely to have made a COVID vaccine response. You get your first dose and then your second dose 3-12 weeks later. You then can have a BOOSTER 6 months later. This is currently open to anyone over 40 in UK. This in my mind should mean anyone with...

Don’t be a technophobe – virtual reality therapy for Fatigue

As darkness falls on the Northern Hemisphere, fatigue, depression and anxiety creep upon the population. For those with MS these symptoms can become unmanageable during this period. Fatigue on average affects 75% of individuals with MS, and affects both physical and mental quality of life. Quality of life is an intangible barometer of well-being with a number of influences that adversely or...

Repairing broken nerves

You have asked about this one. This is not multiple sclerosis but spinal cord injury. In this study they induced a spinal cord injury in animals and injected a scaffolding gel into the nerve injury and the mice showed repair. You can get the information from the scientists themselves, as they have produced a video, but be warned it contains some videos of spinal injured animals Álvarez Z, Kolberg...

Did it Hurt? Vaccine reactions

I have spent most of my MS-life working with Biozzi mice. These were made by Guido Biozzi in Paris to study the genetics of the immune response. At each generation he paired mice making high levels of antibody together and those making low levels of antibody (ABL) after immunization. After about 10-20 generations he made distinct lines. There was the ABH line that made high levels of antibodies...

Progression on Natalizumab

Whilst we sort out what is going on I have agreed to try keep the news coming, as our contributors keep getting run over. However, I am pleased to say I zoomed with Dr Ide Smets today who is well and moving about. As she now has metal plates following surgery I welcomed her to the MSblog “airline club” as I am sure she and ProfG will now get the feeling I have endured for years of...

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