Do antibody levels influence COVID infection in MS?

Impact of mass vaccination on SARS-CoV-2 infections among the total multiple sclerosis population receiving immunomodulatory disease-modifying therapies in England Nikos Evangelou, Afagh Garjani, Sameer Patel, Dhiren Bharkhada, Waqar Rashid, Alasdair Coles, Graham Law Research Squared Doi: 10.21203/

This study aimed to understand changes in the risk of SARS-CoV-2 infection among all people with multiple sclerosis (MS) receiving immunomodulatory disease-modifying therapies (DMTs) in England, compared to the general population, following mass vaccination. Longitudinal data collected by the National Health Service (NHS) England on all MS DMT prescriptions and the UK Health Security Agency on all registered SARS-CoV-2 test results were analysed. The incidence rate ratio of SARS-CoV-2 infection among people with MS taking DMTs compared to the general population was calculated before (November 2020-January 2021) and after (July-August 2021) mass vaccination. Risk of SARS-CoV-2 infection among people on ocrelizumab or fingolimod compared to the general population increased following liberalisation of COVID-19 restrictions (during March-July 2021) despite mass vaccination. No changes were found with other DMTs. These findings converge with the impaired immune response to vaccines observed with ocrelizumab and fingolimod.

I dont need to say much here as you can click and read the paper but is suggests there may be more infections in vaccinated people treated with either fingolimod or ocrelizumab. This might be expected if these two agents block antibody responses following vaccination and antibody levels are important in protecting you from infection

If you want to learn abit more about coroni you can watch a video by Dr Seuhlt and the medcram team. These used to be daily but are now much more infrequent but they explain things better than I can

You can also get info from John Campbell from the UK. He has a very active COVID-19 output

Yep these ar out of date already, such is life around coroni

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