ArchiveJanuary 2022

The MS register reaches 5000

The U.K. MS Register now has 5,000 linked participants. Why not help them get to 5001 or 2. You can volunteer if you live in the United Kingdom. In the year of its 10th Anniversary, the U.K. MS Register has reached a new milestone. By linking with the Register, 5,000 people with MS are not only providing data directly to the MS Register online, but have also agreed to have their NHS medical...

Vaccination-safe disease-modifying treatments

Long time, no COVID posts but today we have Achiron A et al. Ther Adv Neurol Disord. 2021 14:17562864211012835. doi: 10.1177/17562864211012835. Groups is Israel were first to report on the effects of two doses of COVID-19 vaccine. They showed that CD20 depleting antibodies and fingolimod inhibited the antibody response. This led to the suggestion by some that it may not be worth vaccinating...

#AttackMS

AttackMS was conceived on the 29th of Nov 2017 over a beer or two (or was it Elderflower?) at the Lago Maggiore. Prof Jeremy Hobart (Plymouth), ProfG and I sat down on the eve of the annual meeting of the European Charcot Foundation in Baveno, and I said something along the lines of: “Why don’t we treat MS with highly effective disease modifying treatment (HE-DMT) at first...

MS personality

I am not going to comment here as it is more the space for a neuro, who can comment about personalities, but what do you think? I can sometimes see changes in people and knowAre you agreeable? lot:-) Chu L, Casserly C, Rosehart H, Morrow SA. Is there a multiple sclerosis personality? Personality characteristics in newly diagnosed multiple sclerosis and association with mood and cognition. J...

EBV the solution for MS is found or is it?

You said “Could be a missing link into the trigger for MS”. Indeed there has been recent interest in the role of EBV as the cause of MS, and today the link is explained….or is it? Someone else said “If EBV causes MS. Can it now be ruled out the MS isn’t an auto immune disease” Here they looked at B cells in MS brain tissue and that some had been selected and...

The problem for nutriceuticals

You wrote to me to suggest that supplements work…. but this highlights a problem for nutriceutical studies. There is no patent protection to be had and so pharmaceutical companies are not willing to spend big bucks to do a study where anyone can come along and sell the product without any outlay for drug development. So someone says let’s do a prevention study with supplement X…...

MS Awards…Want a gong?

MS Brain Health Awards 2022 – global launchMS Brain Health is launching an annual series of awards to highlight the global impact of MS Brain Health and showcase some examples of the ongoing progress in this area. The first MS Brain Health Awards ceremony will celebrate the work of many healthcare professionals, MS societies and people with MS in addressing the...

What is the cancer risk with MS Disease-modifying treatments?

This question comes up time and again with MS treatments and probably is one of the most important negative selection choices secondary to PML for DMTs in MS. Every time a new drug is presented to the clinical community, the cancer stats are heavily scrutinised. For example, with ocrelizumab the greater number of breast cancers in the treated arm versus placebo impacted on who ultimately received...

Sipping siponimod and other SIPs

Go grab a cup of tea There are a group of drugs used in MS called Sphingosine-1-phosphate receptor modulators. These are known as “the imods”. Here, mod means modulator” and “i” means immune so the immune modulators have been shortened to “imod”. Some people get paid a load of cash to come up with drug names and they have come up with interesting ones...

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