ArchiveFebruary 2022

Disease activity after cessation of fingolimod

Switching fingolimod can mean that as the drug wears-off disease can reacctivate. So you want to make sure that you get on effective treatment before the drug wears-off. How long is that Barboza A, Gaitán MI, Alonso R, Ysrraelit MC, Luetic G, Liwacki S, Patrucco L, Halfon MJ, Burgos M, Mainella C, Pierdabuena R, Recchia L, Steinberg J, Tkachuk VA, Zanga G, Carra A, Chertcoff A, Fernandez Liguori...

Fish show the way to go to repair myelin

For many years we have thought that after demyelination the remyelination is based from oligodendrocyte precursor cells entering the demyelinating region, based on animal models. However, a bombshell was dropped when people tried to date the age of myelinating cells in MS and they suggested that they come from surviving oligodendrocytes. In this study they looked at Zebra fish These animals are...

#MSCOVID

I was wondering if I had presented this one, but there is nothing you havent heard a few times,,,,so I think we can safely say that many people taking ocrelizumb don’t make an antibody response after SARS-CoV-2 but do make a T cell response. We can’t put this idea to bed yet as it will be repeated again a few more times I suspect and we have vaccine three and four to talk about. We...

MS futuroscope: Are you a quitter? 

Free your brain! Source: One of the burning matters in the MS community is how long we should advise pwMS to continue with immune suppressive therapies such as anti-CD20 monoclonal antibodies (mAb) (e.g. ocrelizumab).  Current situation:  At the moment, when you start with anti-CD20 there is no prefixed end date, implying you will continue years and potentially decades with the drug. As the...

Pathologists should play more cluedo:-)

Cluedo is a game where someone gets killed and you have to work out who is the perp, the weapon and the place where the attack took place. Pathology is like murder case (Hopefully this will launch when we were on blogger this word triggered the post to become for 18 year olds) and you are left with the crime scene. You have to work out who dunnit. So you find John Doe in a pristine bedroom. What...

Brain resilience correlates with cognitive performance in MS

What causes cognitive issues in MS? Not a straightforward question to answer. It has been postulated that there is a global cognitive dysfunction in MS largely due to connectivity issues (for example, thalamic grey matter volume loss and also lobar connectivity due to interruptions by MS lesions), but also secondary to cortical MS lesions. What is unknown is the resilience of the whole system and...

Th17 are a menace and must be stopped?

Eksin MA et al. Secukinumab in the treatment of psoriatic arthritis or ankylosing spondyloarthritis with multiple sclerosis: a case series with literature review. Immunotherapy. 2022. doi:10.2217/imt-2021-0128 Plain language summary Background/aim: Multiple sclerosis (MS) is a central nervous system disorder, with rare cases reported to have associated spondyloarthritis (SpA) spectrum...

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