Fish show the way to go to repair myelin


For many years we have thought that after demyelination the remyelination is based from oligodendrocyte precursor cells entering the demyelinating region, based on animal models. However, a bombshell was dropped when people tried to date the age of myelinating cells in MS and they suggested that they come from surviving oligodendrocytes. In this study they looked at Zebra fish

These animals are transparent and you can make them express glo-in the dark myelin so you can see myelination, demyelination and remyelination. The find new myelination coming from precursor cells and that surviving oligodendrocytes have a limited capacity to form new myelin sheaths in vivo. This suggests that therapeutic strategies to promote remyelination through the generation of new oligodendrocytes might be the most promising approach for demyelinating disorders, such as MS.

It would seem unlikely that a basic bit of biology that it has maintained itself from fish to lower mammals like mice and cats would somehow change in humans, but I wish the OPCers would try and repeat the human experiments and show they are not the norm rather than trying to rubbish the human work, e.g. by infering the pathologists had it wrong and the lesions being looked at weren’t remyelinating.

Neely SA, Williamson JM, Klingseisen A, Zoupi L, Early JJ, Williams A, Lyons DA. New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination. Nat Neurosci. 2022. doi: 10.1038/s41593-021-01009-x.

Oligodendrocytes that survive demyelination can remyelinate, including in multiple sclerosis (MS), but how they do so is unclear. In this study, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new myelin to neuronal cell bodies, a pathology we also found in MS. In contrast, oligodendrocytes generated after demyelination make abundant and correctly targeted sheaths, indicating that they likely also have a better regenerative potential in MS.

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  • This is the large scale study that Prof George Jelinek started some years ago as part of his OMS programme (Overcoming Multiple Sclerosis) It is part of the OMS charity and includes his OMS books with a 7 point lifestyle program. Many pwMS use it and it’s very good. I have tried the OMS diet for a few years, but as it was quite similar to the way I ate, fish, fruit and veg it was easy to adopt. I didn’t keep it up as eventually I reintroduced cheese and egg yolks. I haven’t really noticed either an improvement when I used it or a deterioration when I dropped it. The key point though is Prof Jelinek promoted healthy eating. If pwMS keep to something approaching this they will do better that eating a high fat, meat rich diet, but that’s true of many people. So it’s just good sense to eat this way to avoid many modern lifestyle diseases like cardio-vascular, osteo-arthritis etc. We have modern conditions caused be our western diet and we can move to healthier options which will prevent or ameliorate them.

    • Do you know if the diet is similar to Terry Wahls diet? The doctor that in the same way as doctor Jelinek took affaire when no drugs worked an disease developed and studied other ways to reduse disease developement. She claims to get out of the wheelchair and back to her bike klimbing mountains again after eating her diet for a fes years and as one part of the healing. Lots of vegetables, nightfasten 14-16 h, and her moto is Mind my mitocondria. You also have Mathew Embry whos father is a doctor, that started study how to overcome MS when his son got the diagnose. He as well promote diets. As far as I have understood he is not earning money on his organisation MS Hope and give the coocbook away for free.

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