Watch out for Space Travel


Every now and then we get an unusual paper that draws me like a magnet. If you have a few million squid to blow….you may be considering lining the pockets of Elon Musk or Sir Richard Branson for a trip into space….but as you go weight-less, I guess you are pondering what does space do to your oligodendrocytes….Fear not someone has been looking at this….and you can read it, if interested…..

Tran V, Carpo N, Shaka S, Zamudio J, Choi S, Cepeda C, Espinosa-Jeffrey A. Delayed Maturation of Oligodendrocyte Progenitors by Microgravity: Implications for Multiple Sclerosis and Space Flight. Life. 2022; 12:797

In previous studies, we examined the effects of space microgravity on human neural stem cells. To date, there are no studies on a different type of cell that is critical for myelination and electrical signals transmission, oligodendrocyte progenitors (OLPs). The purpose of the present study was to examine the behavior of space-flown OLPs (SPC-OLPs) as they were adapting to Earth’s gravity…….We conclude that microgravity is becoming a novel platform to study why in some myelin disorders OLPs are present but do not mature.

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  • Nice post

    Been looking into this for a while now is seems that space is not a friendly place for your brain

    Brains of cosmonauts get ‘rewired’ to adapt to long-term space missions, study finds

    Living in outer space: Changes in blood flow volume may be at the heart of worsening eyesight

    The longer astronauts stay in space, the more they’ve reported blurry vision and eyesight problems when they return to earth, according to Mark Rosenberg, M.D., a neurology resident at MUSC Health and a researcher on the paper

    Brain damage caused by long stays in space

    Five biomarkers for brain damage were analyzed. They were neurofilament light (NFL), glial fibrillary acidic protein (GFAP), total tau (T-tau), and two amyloid beta proteins.

    For three of the biomarkers—NFL, GFAP and the amyloid beta protein Aβ40—the concentrations were significantly elevated after the space sojourn


  • “To date, there are no studies on …. The most remarkable and surprising finding …. opening two main fields of study to understand …. We conclude that microgravity is becoming a novel platform to study why platform to study why in some myelin disorders OLPs are present but do not mature.”

    All aboard the Remyelination Voyager! See fine healthy young OLPs literally Fail To Mature in microgravity! Feel your heart quiver before the promise, and your research-grant account crack open ….

  • Lol … makes me wonder if my idea of trying out the iFLY experience (air flotation tunnel) could be thought of as therapeutic. 😁 😆

    • I did that many years ago, unless you are in very good shape, I would recommend not to do it. Much harder than it looks like.

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